Back to Search
Start Over
The immunity-diet-microbiota axis in the development of metabolic syndrome.
- Source :
-
Current opinion in lipidology [Curr Opin Lipidol] 2015 Apr; Vol. 26 (2), pp. 73-81. - Publication Year :
- 2015
-
Abstract
- Purpose of Review: Recent evidence demonstrates that the gut-microbiota can be considered as one of the major factors causing metabolic and cardiovascular diseases.<br />Recent Findings: Pattern recognition receptors as well as antimicrobial peptides are a key factor in controlling the intestinal microbiota composition. Deficiencies in these genes lead to changes in the composition of the gut-microbiota, causing leakage of endotoxins into the circulation, and the development of low-grade chronic inflammation and insulin resistance. Dietary composition can also affect the microbiota: a diet rich in saturated fats allows the expansion of pathobionts that damage the intestinal epithelial cell layer and compromise its barrier function. In contrast, a diet high in fiber supports the microbiota to produce short-chain fatty acids, thereby promoting energy expenditure and protecting against inflammation and insulin resistance.<br />Summary: The interactions between the microbiota, innate immunity, and diet play an important role in controlling metabolic homeostasis. A properly functioning innate immune system, combined with a low-fat and high-fiber diet, is important in preventing dysbiosis and reducing the susceptibility to developing the metabolic syndrome and its associated cardiovascular diseases.
Details
- Language :
- English
- ISSN :
- 1473-6535
- Volume :
- 26
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current opinion in lipidology
- Publication Type :
- Academic Journal
- Accession number :
- 25692344
- Full Text :
- https://doi.org/10.1097/MOL.0000000000000154