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Cell penetrating peptides as a therapeutic strategy in chronic lymphocytic leukemia.
- Source :
-
Protein and peptide letters [Protein Pept Lett] 2015; Vol. 22 (6), pp. 539-46. - Publication Year :
- 2015
-
Abstract
- PP2A is a serine/threonine phosphatase critical to a number of physiological and developmental processes. In this manuscript, we show that a peptide, specifically blocking the caspase- 9/PP2A interaction, DPT-C9h, induces apoptosis in primary tumour B cells isolated from peripheral blood mononuclear cells or bone marrow of chronic lymphocytic leukemia (CLL) patients, but not on B cells obtained from healthy donors (HD). Moreover, in both CLL patients and HD, DPT-C9h does not induce apoptosis on T- and NKcells and monocytes. Our results strongly suggest that DPT-C9h peptide has tumour specificity and that caspase-9/PP2Ac interaction constitutes a novel therapeutic approach for the treatment in CLL patients.
Details
- Language :
- English
- ISSN :
- 1875-5305
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Protein and peptide letters
- Publication Type :
- Academic Journal
- Accession number :
- 25687226
- Full Text :
- https://doi.org/10.2174/0929866522666150216115352