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Host Nonresponsiveness Does not Interfere With Vaccine-Mediated Protection Against Gastric Helicobacter Infection.
- Source :
-
Helicobacter [Helicobacter] 2015 Jun; Vol. 20 (3), pp. 217-22. Date of Electronic Publication: 2015 Feb 15. - Publication Year :
- 2015
-
Abstract
- Background: Helicobacter pylori pathogenesis results from the inflammation induced by chronic infection. CBA mice are nonresponsive to gastric Helicobacter infection, providing a useful model for examining host regulation of Helicobacter-induced gastritis. We examined whether gastric Helicobacter nonresponsiveness impacts upon vaccine efficacy and whether immune-mediated protection could occur in the absence of inflammation.<br />Methods: Mice were vaccinated prior to challenge with Helicobacter felis or H. pylori. Gastritis and H. felis colonization was evaluated histologically. H. pylori colonization was quantified by colony-forming assay.<br />Results: Immunizations protected CBA mice against challenge with either H. felis or H. pylori. Protection against H. felis was marked by a loss of nonresponsiveness and development of an atrophic gastritis with mucus metaplasia. However, vaccine-induced protection against H. pylori was only associated with cell infiltration into the gastric mucosa.<br />Conclusions: Nonresponsiveness to gastric Helicobacter infection did not interfere with vaccination-induced protection. Vaccine-induced protective immunity against H. pylori was linked with the induction of cellular infiltration, but importantly not atrophic gastritis.<br /> (© 2015 John Wiley & Sons Ltd.)
- Subjects :
- Animals
Disease Models, Animal
Female
Gastritis, Atrophic prevention & control
Helicobacter Infections prevention & control
Helicobacter felis immunology
Helicobacter pylori immunology
Humans
Inflammation
Metaplasia pathology
Mice
Mice, Inbred CBA
Antibodies, Bacterial immunology
Bacterial Vaccines immunology
Gastric Mucosa immunology
Gastritis, Atrophic immunology
Helicobacter immunology
Helicobacter Infections immunology
Immunization
Stomach immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1523-5378
- Volume :
- 20
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Helicobacter
- Publication Type :
- Academic Journal
- Accession number :
- 25683672
- Full Text :
- https://doi.org/10.1111/hel.12197