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Phenotypic and genetic relationships of bovine natural antibodies binding keyhole limpet hemocyanin in plasma and milk.
- Source :
-
Journal of dairy science [J Dairy Sci] 2015 Apr; Vol. 98 (4), pp. 2746-52. Date of Electronic Publication: 2015 Feb 11. - Publication Year :
- 2015
-
Abstract
- To improve the health status (resilience) of dairy cows, levels of natural antibodies (NAb) might be useful. The objective of the present study was to compare levels and to estimate genetic parameters for NAb measured in milk and plasma samples. Titers of NAb IgM and IgG isotype-binding keyhole limpet hemocyanin of 2,919 cows, in both plasma and milk, were measured using ELISA. Analysis revealed that NAb levels in milk significantly increased with parity, whereas they remained constant in plasma. Moderate positive phenotypic correlations were found between NAb levels in milk and in plasma: 0.18 for IgG and 0.40 for IgM. This indicates that NAb from milk and plasma might reflect different aspects of dairy cow health status. However, high genetic correlations were found for NAb in milk and plasma: 0.81 for IgG and 0.79 for IgM. Heritabilities (SE in parentheses) for NAb measured in plasma [0.15 (0.05) for IgG and 0.25 (0.06) for IgM] were higher than heritabilities of NAb measured in milk [0.08 (0.03) for IgG and 0.23 (0.05) for IgM]. Our results indicate that NAb measured in milk and plasma are heritable and likely have a common genetic background, suggesting that NAb levels measured in milk might be useful for genetic improvement of disease resistance.<br /> (Copyright © 2015 American Dairy Science Association. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Cattle blood
Cattle genetics
Cattle immunology
Enzyme-Linked Immunosorbent Assay veterinary
Female
Immunity, Innate immunology
Immunoglobulin G chemistry
Immunoglobulin M blood
Immunoglobulin M chemistry
Milk chemistry
Parity immunology
Pregnancy
Cattle metabolism
Hemocyanins chemistry
Immunoglobulin G metabolism
Immunoglobulin M metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1525-3198
- Volume :
- 98
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of dairy science
- Publication Type :
- Academic Journal
- Accession number :
- 25682147
- Full Text :
- https://doi.org/10.3168/jds.2014-8818