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Stromal CD8+ T-cell Density—A Promising Supplement to TNM Staging in Non-Small Cell Lung Cancer.
- Source :
-
Clinical cancer research : an official journal of the American Association for Cancer Research [Clin Cancer Res] 2015 Jun 01; Vol. 21 (11), pp. 2635-43. Date of Electronic Publication: 2015 Feb 13. - Publication Year :
- 2015
-
Abstract
- Purpose: Immunoscore is a prognostic tool defined to quantify in situ immune cell infiltrates, which appears to be superior to the tumor-node-metastasis (TNM) classification in colorectal cancer. In non-small cell lung cancer (NSCLC), no immunoscore has been established, but in situ tumor immunology is recognized as highly important. We have previously evaluated the prognostic impact of several immunological markers in NSCLC, yielding the density of stromal CD8(+) tumor-infiltrating lymphocytes (TIL) as the most promising candidate. Hence, we validate the impact of stromal CD8(+) TIL density as an immunoscore in NSCLC.<br />Experimental Design: The prognostic impact of stromal CD8(+) TILs was evaluated in four different cohorts from Norway and Denmark consisting of 797 stage I-IIIA NSCLC patients. The Tromso cohort (n = 155) was used as training set, and the results were further validated in the cohorts from Bodo (n = 169), Oslo (n = 295), and Denmark (n = 178). Tissue microarrays and clinical routine CD8 staining were used for all cohorts.<br />Results: Stromal CD8(+) TIL density was an independent prognostic factor in the total material (n = 797) regardless of the endpoint: disease-free survival (P < 0.001), disease-specific survival (P < 0.001), or overall survival (P < 0.001). Subgroup analyses revealed significant prognostic impact of stromal CD8(+) TIL density within each pathologic stage (pStage). In multivariate analysis, stromal CD8(+) TIL density and pStage were independent prognostic variables.<br />Conclusions: Stromal CD8(+) TIL density has independent prognostic impact in resected NSCLC, adds prognostic impact within each pStage, and is a good candidate marker for establishing a TNM-Immunoscore.<br /> (©2015 American Association for Cancer Research.)
- Subjects :
- Aged
Biomarkers, Tumor immunology
CD8-Positive T-Lymphocytes pathology
Carcinoma, Non-Small-Cell Lung pathology
Carcinoma, Non-Small-Cell Lung surgery
Disease-Free Survival
Female
Humans
Lymphocytes, Tumor-Infiltrating pathology
Male
Middle Aged
Neoplasm Metastasis
Neoplasm Staging
Prognosis
Stromal Cells pathology
CD8-Positive T-Lymphocytes immunology
Carcinoma, Non-Small-Cell Lung immunology
Cell Count
Lymphocytes, Tumor-Infiltrating immunology
Stromal Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1557-3265
- Volume :
- 21
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Clinical cancer research : an official journal of the American Association for Cancer Research
- Publication Type :
- Academic Journal
- Accession number :
- 25680376
- Full Text :
- https://doi.org/10.1158/1078-0432.CCR-14-1905