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External knee adduction and flexion moments during gait and medial tibiofemoral disease progression in knee osteoarthritis.
- Source :
-
Osteoarthritis and cartilage [Osteoarthritis Cartilage] 2015 Jul; Vol. 23 (7), pp. 1099-106. Date of Electronic Publication: 2015 Feb 10. - Publication Year :
- 2015
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Abstract
- Objective: Test the hypothesis that greater baseline peak external knee adduction moment (KAM), KAM impulse, and peak external knee flexion moment (KFM) during the stance phase of gait are associated with baseline-to-2-year medial tibiofemoral cartilage damage and bone marrow lesion progression, and cartilage thickness loss.<br />Methods: Participants all had knee OA in at least one knee. Baseline peak KAM, KAM impulse, and peak KFM (normalized to body weight and height) were captured and computed using a motion analysis system and six force plates. Participants underwent MRI of both knees at baseline and 2 years later. To assess the association between baseline moments and baseline-to-2-year semiquantitative cartilage damage and bone marrow lesion progression and quantitative cartilage thickness loss, we used logistic and linear regressions with generalized estimating equations (GEE), adjusting for gait speed, age, gender, disease severity, knee pain severity, and medication use.<br />Results: The sample consisted of 391 knees (204 persons): mean age 64.2 years (SD 10.0); BMI 28.4 kg/m(2) (5.7); 156 (76.5%) women. Greater baseline peak KAM and KAM impulse were each associated with worsening of medial bone marrow lesions, but not cartilage damage. Higher baseline KAM impulse was associated with 2-year medial cartilage thickness loss assessed both as % loss and as a threshold of loss, whereas peak KAM was related only to % loss. There was no relationship between baseline peak KFM and any medial disease progression outcome measures.<br />Conclusion: Findings support targeting KAM parameters in an effort to delay medial OA disease progression.<br /> (Copyright © 2015 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.)
- Subjects :
- Aged
Bone Marrow pathology
Cartilage, Articular pathology
Disease Progression
Female
Humans
Longitudinal Studies
Magnetic Resonance Imaging
Male
Middle Aged
Osteoarthritis, Knee pathology
Prospective Studies
Gait physiology
Knee Joint physiopathology
Osteoarthritis, Knee physiopathology
Range of Motion, Articular physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1522-9653
- Volume :
- 23
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Osteoarthritis and cartilage
- Publication Type :
- Academic Journal
- Accession number :
- 25677110
- Full Text :
- https://doi.org/10.1016/j.joca.2015.02.005