The 148 M allele of the PNPLA3 is associated with plasma irisin levels in a population sample of Caucasian children: The PANIC Study.

Authors :: Viitasalo A
Atalay M
Pihlajamäki J
Jääskeläinen J
Korkmaz A
Kaminska D
Lindi V
Lakka TA
Source :: Metabolism: clinical and experimental [Metabolism] 2015 Jul; Vol. 64 (7), pp. 793-6. Date of Electronic Publication: 2015 Jan 28.
Publication Year :: 2015
Abstract: Background: There are no previous data on the association of PNPLA3 I148M polymorphism (rs738409) with circulating adipokines and myokines in children.<br />Subjects/methods: Subjects were a population sample of 481 Caucasian children aged 6-8 years. We assessed circulating levels of irisin together with IL-6, TNF-α, leptin, high molecular weight (HMW)-adiponectin, alanine aminotransferase (ALT) and gamma-glutamyl transferase (GGT) while the subjects were stratified according to PNPLA3 I148M variants.<br />Results: The PNPLA3 rs738409 polymorphism had a linear relationship with plasma levels of irisin after adjustment for age, sex and body height (p=0.007) but it was not associated with circulating levels of interleukin- 6 (IL-6), tumor-necrosis factor α (TNF-α), leptin or HMW-adiponectin.<br />Conclusion: PNPLA3 148M allele carriers had higher plasma levels of irisin than the non-carriers. This might be due to compensatory mechanism to limit early steatotic and inflammatory changes in the liver.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)

Subjects :: Adipokines blood
Alanine Transaminase blood
Alleles
Child
Female
Genotype
Humans
Interleukin-6 blood
Leptin blood
Male
Polymorphism, Genetic genetics
Risk Factors
Tumor Necrosis Factor-alpha blood
gamma-Glutamyltransferase blood
Fibronectins blood
Lipase genetics
Membrane Proteins genetics
White People genetics

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