Creeping proteins in microporous structures: polymer brush-assisted fabrication of 3D gradients for tissue engineering.

Authors :: Gunnewiek MK
Di Luca A
Bollemaat HZ
van Blitterswijk CA
Vancso GJ
Moroni L
Benetti EM
Source :: Advanced healthcare materials [Adv Healthc Mater] 2015 Jun 03; Vol. 4 (8), pp. 1169-74. Date of Electronic Publication: 2015 Feb 13.
Publication Year :: 2015
Abstract: Coupling of rapid prototyping techniques and surface-confined polymerizations allows the fabrication of 3D multidirectional gradients of biomolecules within microporous scaffolds. The compositional gradients can be tailored by polymer-brush-assisted diffusion of protein solutions. This technique allows spatial control over stem cells manipulation within 3D environments.<br /> (© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.)

Subjects :: Biocompatible Materials chemistry
Cells, Cultured
Cells, Immobilized
Humans
Mesenchymal Stem Cells
Models, Theoretical
Polyethylene Glycols chemistry
Polymerization
Tissue Scaffolds
Polymers chemistry
Proteins chemistry
Tissue Engineering methods

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