Back to Search
Start Over
Periodontal Health in Women With Early-Stage Postmenopausal Breast Cancer Newly on Aromatase Inhibitors: A Pilot Study.
- Source :
-
Journal of periodontology [J Periodontol] 2015 Jul; Vol. 86 (7), pp. 906-16. Date of Electronic Publication: 2015 Feb 12. - Publication Year :
- 2015
-
Abstract
- Background: Aromatase inhibitor (AI) use results in low estrogen levels, which in turn affect bone mineral density (BMD). Periodontitis, alveolar bone loss, and tooth loss are associated with low BMD. The goal of this study is to assess the prevalence of periodontitis and perceived oral health and evaluate salivary biomarkers in postmenopausal women who are survivors of early-stage (I to IIIA) breast cancer (BCa) and receive adjuvant AI therapy.<br />Methods: Participants included 58 postmenopausal women: 29 with BCa on AIs and 29 controls without BCa diagnoses. Baseline periodontal status was assessed with: 1) periodontal probing depth (PD); 2) bleeding on probing (BOP); and 3) attachment loss (AL). Demographic and dental utilization information was gathered by questionnaire. Linear regression modeling was used to analyze the outcomes.<br />Results: No differences were found in mean PD or number of teeth. The AI group had significantly more sites with BOP (27.8 versus 16.7; P = 0.02), higher worst-site AL (5.2 versus 4.0 mm; P <0.01), and more sites with dental calculus (18.2 versus 6.4; P <0.001) than controls. Linear regression adjusted for income, tobacco use, dental insurance, and previous radiation and chemotherapy exposure demonstrated that AI use increased AL by >2 mm (95% confidence interval, 0.46 to 3.92). Median salivary osteocalcin and tumor necrosis factor-α levels were significantly higher in the AI group than the control group.<br />Conclusion: This first investigation of the periodontal status of women initiating adjuvant AI therapy identifies this population as having an increased risk for periodontitis.
- Subjects :
- Adult
Aged
Biomarkers analysis
Dental Calculus classification
Dental Plaque Index
Female
Gingival Recession classification
Humans
Middle Aged
Neoplasm Staging
Oral Health
Osteocalcin analysis
Periodontal Attachment Loss classification
Periodontal Pocket classification
Periodontitis classification
Pilot Projects
Radiography, Bitewing methods
Saliva chemistry
Tooth Loss classification
Tumor Necrosis Factor-alpha analysis
Antineoplastic Agents, Hormonal therapeutic use
Aromatase Inhibitors therapeutic use
Breast Neoplasms drug therapy
Periodontal Index
Postmenopause
Subjects
Details
- Language :
- English
- ISSN :
- 1943-3670
- Volume :
- 86
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Journal of periodontology
- Publication Type :
- Academic Journal
- Accession number :
- 25672657
- Full Text :
- https://doi.org/10.1902/jop.2015.140546