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SUZ12 promotes gastric cancer cell proliferation and metastasis by regulating KLF2 and E-cadherin.
- Source :
-
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine [Tumour Biol] 2015 Jul; Vol. 36 (7), pp. 5341-51. Date of Electronic Publication: 2015 Feb 12. - Publication Year :
- 2015
-
Abstract
- SUZ12 is a core component of the polycomb repressive complex 2 (PRC2), which could silence gene transcription by generating trimethylation on lysine 27 residue of histone H3 (H3K27Me3). Meanwhile, SUZ12 has been found to be overexpressed in multiple cancers; however, the clinical significance and molecular mechanisms of SUZ12 controlling gastric cancer cell proliferation and metastasis are unclear. In this study, we found that SUZ12 expression was significantly increased in 64 gastric tumor tissues compared with normal tissues. Additionally, SUZ12 expression was associated with pathological stage, metastasis distance, and shorter overall survival of gastric cancer patients. Knockdown of SUZ12 expression impaired cell proliferation and invasion in vitro, leading to the inhibition of metastasis in vivo. Upregulation of SUZ12 was found to play a key role in gastric cancer cell proliferation and metastasis through the regulation of EMT and KLF2 expression.
- Subjects :
- Adult
Aged
Animals
Cadherins genetics
Cell Line, Tumor
Cell Proliferation genetics
Epithelial-Mesenchymal Transition genetics
Female
Gene Expression Regulation, Neoplastic
Humans
Kruppel-Like Transcription Factors genetics
Male
Mice
Middle Aged
Neoplasm Invasiveness genetics
Neoplasm Metastasis
Neoplasm Proteins
Neoplasm Staging
Polycomb Repressive Complex 2 biosynthesis
Stomach Neoplasms pathology
Transcription Factors
Xenograft Model Antitumor Assays
Cadherins biosynthesis
Kruppel-Like Transcription Factors biosynthesis
Polycomb Repressive Complex 2 genetics
Stomach Neoplasms genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0380
- Volume :
- 36
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 25672609
- Full Text :
- https://doi.org/10.1007/s13277-015-3195-7