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Early-life dietary spray-dried plasma influences immunological and intestinal injury responses to later-life Salmonella typhimurium challenge.
- Source :
-
The British journal of nutrition [Br J Nutr] 2015 Mar 14; Vol. 113 (5), pp. 783-93. Date of Electronic Publication: 2015 Feb 11. - Publication Year :
- 2015
-
Abstract
- Increasing evidence supports the concept that early-life environmental influences, including nutrition and stress, have an impact on long-term health outcomes and disease susceptibility. The objective of the present study was to determine whether dietary spray-dried plasma (SDP), fed during the first 2 weeks post-weaning (PW), influences subsequent immunological and intestinal injury responses to Salmonella typhimurium challenge. A total of thirty-two piglets (age 16-17 d) were weaned onto nursery diets containing 0, 2·5 % SDP (fed for 7 d PW) or 5 % SDP (fed for 14 d PW), and were then fed control diets (without SDP), for the remainder of the experiment. At 34 d PW (age 50 d), pigs were challenged with 3 × 10⁹ colony-forming units of S. typhimurium. A control group (non-challenged) that was fed 0 % SDP in the nursery was included. At 2 d post-challenge, the distal ileum was harvested for the measurement of inflammatory, histological and intestinal physiological parameters. S. typhimurium challenge induced elevated ileal histological scores, myeloperoxidase (MPO), IL-8 and TNF, and increased intestinal permeability (indicated by reduced transepithelial voltage (potential difference) and elevated 4 kDa fluorescein isothiocyanate dextran (FD4) flux rates). Compared with S. typhimurium-challenged controls (0 % SDP), pigs fed the 5 % SDP-14 d diet exhibited reduced ileal histological scores, MPO levels, IL-8 levels and FD4 flux rates. Pigs fed the 5 % SDP-14 d nursery diet exhibited increased levels of plasma and ileal TNF-α in response to the challenge, compared with the other treatments. These results indicate that inclusion of SDP in PW diets can have an influence on subsequent immunological and intestinal injury responses induced by later-life S. typhimurium challenge.
- Subjects :
- Animals
Biomarkers blood
Biomarkers metabolism
Blood Proteins administration & dosage
Crosses, Genetic
Cytokines blood
Cytokines metabolism
Diet adverse effects
Energy Intake
Enterocolitis immunology
Enterocolitis microbiology
Enterocolitis prevention & control
Feces microbiology
Female
Ileum immunology
Ileum metabolism
Ileum microbiology
Ileum pathology
Immunity, Mucosal
Immunotherapy adverse effects
Intestinal Mucosa immunology
Intestinal Mucosa metabolism
Intestinal Mucosa microbiology
Intestinal Mucosa pathology
Male
Salmonella Infections, Animal immunology
Salmonella Infections, Animal metabolism
Salmonella Infections, Animal microbiology
Salmonella typhimurium growth & development
Salmonella typhimurium isolation & purification
Sus scrofa
Swine
Swine Diseases immunology
Swine Diseases metabolism
Swine Diseases microbiology
Weaning
Weight Gain
Blood Proteins therapeutic use
Diet veterinary
Enterocolitis veterinary
Immunotherapy veterinary
Salmonella Infections, Animal prevention & control
Salmonella typhimurium immunology
Swine Diseases prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1475-2662
- Volume :
- 113
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The British journal of nutrition
- Publication Type :
- Academic Journal
- Accession number :
- 25671331
- Full Text :
- https://doi.org/10.1017/S000711451400422X