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Effects of acute systemic administration of TiO2, ZnO, SiO2, and Ag nanoparticles on hemodynamics, hemostasis and leukocyte recruitment.
- Source :
-
Nanotoxicology [Nanotoxicology] 2015; Vol. 9 (8), pp. 963-71. Date of Electronic Publication: 2015 Feb 11. - Publication Year :
- 2015
-
Abstract
- It has been suggested that engineered nanomaterials (ENM), once arrived in the circulation, may affect the cardiovascular system. The aim of this in vivo study was to screen major cardiovascular effects of acute systemic administration of a panel of five nanomaterials, TiO2 anatase (NM-101), TiO2 rutile (NM-104), ZnO (NM-110), SiO2 (NM-200) and Ag (NM-300). Mice were anesthetized and the ENM were injected at a dose of 1 mg/kg via a catheter placed in the left femoral artery. Hemodynamic parameters were determined by invasive measurement of blood pressure and non-invasive measurement of heart rate. Ten minutes after injection of the ENM, the formation of light/dye-induced thrombi was assessed in the cremasteric microcirculation by intravital microscopy. In addition, the numbers of rolling, firmly adherent and transmigrated leukocytes were recorded in postcapillary cremasteric venules over a time period of 120 min after injection of ENM by intravital microscopy. The systemic administration of a single dose of the ENM tested did not dramatically alter hemodynamic parameters or affect early steps of leukocyte recruitment. However, the presence of circulating TiO2 anatase, but not of TiO2 rutile, SiO2, ZnO or Ag nanoparticles, significantly accelerated thrombus formation in the murine microcirculation. Moreover, TiO2 anatase but not TiO2 rutile nanoparticles increased murine platelet aggregation in vitro. Taken together, only one of the five systemically administered ENM, TiO2 anatase, affected hemostasis, whereas none of the ENM tested in this screening study dramatically modulated hemodynamic parameters or early steps of leukocyte recruitment.
- Subjects :
- Animals
Male
Metal Nanoparticles chemistry
Mice
Microcirculation drug effects
Platelet Aggregation drug effects
Silicon Dioxide administration & dosage
Silicon Dioxide chemistry
Silver chemistry
Silver toxicity
Thrombosis chemically induced
Titanium administration & dosage
Titanium chemistry
Zinc Oxide chemistry
Hemodynamics drug effects
Hemostasis drug effects
Leukocyte Rolling drug effects
Metal Nanoparticles administration & dosage
Metal Nanoparticles toxicity
Silicon Dioxide toxicity
Titanium toxicity
Zinc Oxide toxicity
Subjects
Details
- Language :
- English
- ISSN :
- 1743-5404
- Volume :
- 9
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Nanotoxicology
- Publication Type :
- Academic Journal
- Accession number :
- 25670207
- Full Text :
- https://doi.org/10.3109/17435390.2014.992815