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RORA gene rs12912233 and rs880626 polymorphisms and their interaction with SCN1A rs3812718 in the risk of epilepsy: a case-control study in Malaysia.
- Source :
-
Genomics [Genomics] 2015 Apr; Vol. 105 (4), pp. 229-36. Date of Electronic Publication: 2015 Feb 07. - Publication Year :
- 2015
-
Abstract
- RAR-related orphan receptors A (RORA) and B (RORB) and voltage-gated sodium channel type 1 (SCN1A) genes play critical roles in the regulation of the circadian clock. Evidence has shown an association of RORA and RORB polymorphisms with susceptibility to autism and depression. Hence, we tested the association of RORA rs12912233, rs16943429, rs880626, rs2290430, and rs12900948; RORB rs1157358, rs7022435, rs3750420, and rs3903529; and SCN1A rs3812718 with epilepsy risk in the Malaysians. DNA was genotyped in 1789 subjects (39% epilepsy patients) by using MassARRAY (Sequenom). Significant association was obtained for rs12912233 in Malaysian Chinese (p=0.003). Interaction between rs12912233-rs880626 and rs3812718 was associated with the epilepsy risk in the subjects overall (p=0.001). Results show that RORA rs12912233 alone might be a possible risk variant for epilepsy in Malaysian Chinese, but that, together with RORA rs880626 and SCN1A rs3812718, this polymorphism may have a synergistic effect in the epilepsy risk in Malaysians.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Adolescent
Adult
Case-Control Studies
Epilepsy epidemiology
Female
Humans
Malaysia
Male
Middle Aged
Nuclear Receptor Subfamily 1, Group F, Member 2 genetics
Risk
Young Adult
Epilepsy genetics
Epistasis, Genetic
Genetic Predisposition to Disease
NAV1.1 Voltage-Gated Sodium Channel genetics
Nuclear Receptor Subfamily 1, Group F, Member 1 genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1089-8646
- Volume :
- 105
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Genomics
- Publication Type :
- Academic Journal
- Accession number :
- 25668517
- Full Text :
- https://doi.org/10.1016/j.ygeno.2015.02.001