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Human papillomavirus antibodies and future risk of anogenital cancer: a nested case-control study in the European prospective investigation into cancer and nutrition study.
- Source :
-
Journal of clinical oncology : official journal of the American Society of Clinical Oncology [J Clin Oncol] 2015 Mar 10; Vol. 33 (8), pp. 877-84. Date of Electronic Publication: 2015 Feb 09. - Publication Year :
- 2015
-
Abstract
- Purpose: Human papillomavirus (HPV) type 16 (HPV16) causes cancer at several anatomic sites. In the European Prospective Investigation Into Cancer and Nutrition study, HPV16 E6 seropositivity was present more than 10 years before oropharyngeal cancer diagnosis and was nearly absent in controls. The current study sought to evaluate the extent to which HPV16 E6 antibodies are present before diagnosis of anogenital cancers within the same cohort.<br />Methods: Four hundred incident anogenital cancers (273 cervical, 24 anal, 67 vulvar, 12 vaginal, and 24 penile cancers) with prediagnostic blood samples (collected on average 3 and 8 years before diagnosis for cervix and noncervix cancers, respectively) and 718 matched controls were included. Plasma was analyzed for antibodies against HPV16 E6 and multiple other HPV proteins and genotypes and evaluated in relation to risk using unconditional logistic regression.<br />Results: HPV16 E6 seropositivity was present in 29.2% of individuals (seven of 24 individuals) who later developed anal cancer compared with 0.6% of controls (four of 718 controls) who remained cancer free (odds ratio [OR], 75.9; 95% CI, 17.9 to 321). HPV16 E6 seropositivity was less common for cancers of the cervix (3.3%), vagina (8.3%), vulva (1.5%), and penis (8.3%). No associations were seen for non-type 16 HPV E6 antibodies, apart from anti-HPV58 E6 and anal cancer (OR, 6.8; 95% CI, 1.4 to 33.1). HPV16 E6 seropositivity tended to increase in blood samples drawn closer in time to cancer diagnosis.<br />Conclusion: HPV16 E6 seropositivity is relatively common before diagnosis of anal cancer but rare for other HPV-related anogenital cancers.<br /> (© 2015 by American Society of Clinical Oncology.)
- Subjects :
- Adult
Aged
Anus Neoplasms virology
Biomarkers, Tumor
Case-Control Studies
Europe
Female
Follow-Up Studies
Genital Neoplasms, Female virology
Genital Neoplasms, Male virology
Genotype
Humans
Male
Middle Aged
Nutritional Sciences
Oncogene Proteins, Viral immunology
Papillomaviridae
Papillomavirus Infections complications
Prospective Studies
Repressor Proteins immunology
Treatment Outcome
Antibodies, Viral blood
Anus Neoplasms immunology
Genital Neoplasms, Female immunology
Genital Neoplasms, Male immunology
Papillomavirus Infections immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1527-7755
- Volume :
- 33
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of clinical oncology : official journal of the American Society of Clinical Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 25667279
- Full Text :
- https://doi.org/10.1200/JCO.2014.57.8435