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Effects on lung stress of position and different doses of perfluorocarbon in a model of ARDS.
- Source :
-
Respiratory physiology & neurobiology [Respir Physiol Neurobiol] 2015 May; Vol. 210, pp. 30-7. Date of Electronic Publication: 2015 Feb 07. - Publication Year :
- 2015
-
Abstract
- We determined whether the combination of low dose partial liquid ventilation (PLV) with perfluorocarbons (PFC) and prone positioning improved lung function while inducing minimal stress. Eighteen pigs with acute lung injury were assigned to conventional mechanical ventilation (CMV) or PLV (5 or 10 ml/kg of PFC). Positive end-expiratory pressure (PEEP) trials in supine and prone positions were performed. Data were analyzed by a multivariate polynomial regression model. The interplay between PLV and position depended on the PEEP level. In supine PLV dampened the stress induced by increased PEEP during the trial. The PFC dose of 5 ml/kg was more effective than the dose 10 ml/kg. This effect was not observed in prone. Oxygenation was significantly higher in prone than in supine position mainly at lower levels of PEEP. In conclusion, MV settings should take both gas exchange and stress/strain into account. When protective CMV fails, rescue strategies combining prone positioning and PLV with optimal PEEP should improve gas exchange with minimal stress.<br /> (Copyright © 2015 Elsevier B.V. All rights reserved.)
- Subjects :
- Acute Lung Injury physiopathology
Acute Lung Injury therapy
Animals
Blood Gas Analysis
Cardiovascular Agents pharmacology
Disease Models, Animal
Dose-Response Relationship, Drug
Hemodynamics drug effects
Hemodynamics physiology
Male
Oleic Acids pharmacology
Positive-Pressure Respiration
Respiration, Artificial
Respiratory Distress Syndrome physiopathology
Stress, Physiological drug effects
Stress, Physiological physiology
Supine Position physiology
Swine
Fluorocarbons pharmacology
Liquid Ventilation methods
Lung drug effects
Lung physiopathology
Prone Position physiology
Respiratory Distress Syndrome therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1878-1519
- Volume :
- 210
- Database :
- MEDLINE
- Journal :
- Respiratory physiology & neurobiology
- Publication Type :
- Academic Journal
- Accession number :
- 25662756
- Full Text :
- https://doi.org/10.1016/j.resp.2015.01.016