Back to Search
Start Over
Antivascular and anti-parasite activities of natural and hemisynthetic flavonoids from New Caledonian Gardenia species (Rubiaceae).
- Source :
-
European journal of medicinal chemistry [Eur J Med Chem] 2015 Mar 26; Vol. 93, pp. 93-100. Date of Electronic Publication: 2015 Jan 08. - Publication Year :
- 2015
-
Abstract
- A series of 16 flavonoids were isolated and prepared from bud exudate of Gardenia urvillei and Gardenia oudiepe, endemic to New Caledonia. Most of them are rare polymethoxylated flavones. Some of these compounds showed noticeable activity against Leishmania (Leishmania) amazonensis, Plasmodium falciparum and Trypanosoma brucei gambiense, in addition to tubulin polymerization inhibition at low micromolar concentration. We also provide a full set of NMR data as some of the flavones were incompletely described.<br /> (Copyright © 2015 Elsevier Masson SAS. All rights reserved.)
- Subjects :
- Angiogenesis Inhibitors chemical synthesis
Angiogenesis Inhibitors chemistry
Angiogenesis Inhibitors isolation & purification
Animals
Antiparasitic Agents chemical synthesis
Antiparasitic Agents chemistry
Antiparasitic Agents isolation & purification
Cell Line, Tumor
Cell Survival drug effects
Drug Design
Flavonoids chemical synthesis
Flavonoids chemistry
Flavonoids isolation & purification
Flowers chemistry
Humans
Leishmania drug effects
Molecular Structure
New Caledonia
Plasmodium falciparum drug effects
Structure-Activity Relationship
Trypanosoma brucei gambiense drug effects
Angiogenesis Inhibitors pharmacology
Antiparasitic Agents pharmacology
Flavonoids pharmacology
Gardenia chemistry
Plant Extracts chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1768-3254
- Volume :
- 93
- Database :
- MEDLINE
- Journal :
- European journal of medicinal chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25659770
- Full Text :
- https://doi.org/10.1016/j.ejmech.2015.01.012