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Isoflavones in food supplements: chemical profile, label accordance and permeability study in Caco-2 cells.
- Source :
-
Food & function [Food Funct] 2015 Mar; Vol. 6 (3), pp. 938-46. - Publication Year :
- 2015
-
Abstract
- Consumers nowadays are playing an active role in their health-care. A special case is the increasing number of women, who are reluctant to use exogenous hormone therapy for the treatment of menopausal symptoms and are looking for complementary therapies. However, food supplements are not clearly regulated in Europe. The EFSA has only recently begun to address the issues of botanical safety and purity regulation, leading to a variability of content, standardization, dosage, and purity of available products. In this study, isoflavones (puerarin, daidzin, genistin, daidzein, glycitein, genistein, formononetin, prunetin, and biochanin A) from food supplements (n = 15) for menopausal symptoms relief are evaluated and compared with the labelled information. Only four supplements complied with the recommendations made by the EC on the tolerable thresholds. The intestinal bioavailability of these compounds was investigated using Caco-2 cells. The apparent permeability coefficients of the selected isoflavonoids across the Caco-2 cells were affected by the isoflavone concentration and product matrix.
- Subjects :
- Absorption, Physiological
Australia
Caco-2 Cells
Cell Membrane Permeability
Dietary Supplements economics
Dietary Supplements standards
European Union
Female
Food Additives adverse effects
Food Additives analysis
Food Additives chemistry
Food Inspection
Food Labeling
Guidelines as Topic
Humans
Isoflavones chemistry
Isoflavones metabolism
Molecular Structure
Osmolar Concentration
Phytoestrogens chemistry
Phytoestrogens metabolism
Phytoestrogens standards
Postmenopause
Self Care
United States
Dietary Supplements analysis
Enterocytes metabolism
Intestinal Absorption
Isoflavones analysis
Phytoestrogens analysis
Subjects
Details
- Language :
- English
- ISSN :
- 2042-650X
- Volume :
- 6
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Food & function
- Publication Type :
- Academic Journal
- Accession number :
- 25653232
- Full Text :
- https://doi.org/10.1039/c4fo01144a