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Repairing the broken market for antibiotic innovation.
- Source :
-
Health affairs (Project Hope) [Health Aff (Millwood)] 2015 Feb; Vol. 34 (2), pp. 277-85. - Publication Year :
- 2015
-
Abstract
- Multidrug-resistant bacterial diseases pose serious and growing threats to human health. While innovation is important to all areas of health research, it is uniquely important in antibiotics. Resistance destroys the fruit of prior research, making it necessary to constantly innovate to avoid falling back into a pre-antibiotic era. But investment is declining in antibiotics, driven by competition from older antibiotics, the cost and uncertainty of the development process, and limited reimbursement incentives. Good public health practices curb inappropriate antibiotic use, making return on investment challenging in payment systems based on sales volume. We assess the impact of recent initiatives to improve antibiotic innovation, reflecting experience with all sixty-seven new molecular entity antibiotics approved by the Food and Drug Administration since 1980. Our analysis incorporates data and insights derived from several multistakeholder initiatives under way involving governments and the private sector on both sides of the Atlantic. We propose three specific reforms that could revitalize innovations that protect public health, while promoting long-term sustainability: increased incentives for antibiotic research and development, surveillance, and stewardship; greater targeting of incentives to high-priority public health needs, including reimbursement that is delinked from volume of drug use; and enhanced global collaboration, including a global treaty.<br /> (Project HOPEāThe People-to-People Health Foundation, Inc.)
- Subjects :
- Anti-Bacterial Agents adverse effects
Anti-Bacterial Agents standards
Bacterial Infections drug therapy
Biomedical Research standards
Biomedical Research trends
Clinical Trials as Topic economics
Clinical Trials as Topic standards
Drug Approval economics
Drug Approval legislation & jurisprudence
Drug Costs trends
Drug Industry standards
Drug Industry trends
Financing, Government standards
Financing, Government trends
Humans
International Cooperation
Organizational Innovation economics
Orphan Drug Production economics
Orphan Drug Production legislation & jurisprudence
Prescription Fees trends
Product Surveillance, Postmarketing economics
Product Surveillance, Postmarketing standards
Product Surveillance, Postmarketing trends
Public Health standards
Public Health trends
Public-Private Sector Partnerships economics
Public-Private Sector Partnerships trends
Reimbursement, Incentive economics
Reimbursement, Incentive legislation & jurisprudence
Reimbursement, Incentive trends
United States
Anti-Bacterial Agents economics
Bacterial Infections economics
Biomedical Research economics
Drug Industry economics
Drug Resistance, Multiple, Bacterial drug effects
Public Health economics
Subjects
Details
- Language :
- English
- ISSN :
- 1544-5208
- Volume :
- 34
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Health affairs (Project Hope)
- Publication Type :
- Academic Journal
- Accession number :
- 25646108
- Full Text :
- https://doi.org/10.1377/hlthaff.2014.1003