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Interstitial Fluid Pressure Correlates Clinicopathological Factors of Lung Cancer.
- Source :
-
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia [Ann Thorac Cardiovasc Surg] 2015; Vol. 21 (3), pp. 201-8. Date of Electronic Publication: 2015 Jan 26. - Publication Year :
- 2015
-
Abstract
- Purpose: Solid tumors show increased interstitial fluid pressure (IFP), which correlates to a number of pathophysiological features of tumors. There have been no reports on the usefulness of measuring IFP in lung cancer. The aim of this study was to examine the relationship between IFP and the clinicopathological characteristics of lung cancer.<br />Methods: IFP was measured prospectively in 215 patients with 219 lesions showing solid or part-solid appearance. Four patients with double lung cancer were excluded from the analysis, resulting in 211 patients with lung cancer being analyzed for the correlation between IFP and computed tomography (CT) appearance, size, Tumor-node-metastasis (TNM) classification, maximal standardized uptake value (SUVmax), histological type, tumor grade, pleural and vessel invasion, Ki-67 index, and recurrence-free survival (RFS).<br />Results: The mean IFP was 8.5 mmHg; IFP was significantly correlated with the tumor size, SUVmax, TNM, vessel and pleural invasion, and Ki-67 index. Low IFP was associated with a better RFS compared to high IFP. Multivariate analysis did not select IFP as independent prognostic factor. In subgroup analysis of patients with adenocarcinoma, IFP was selected as independent one.<br />Conclusions: IFP correlates clinicopathological factors of lung cancer. IFP might be used as a prognostic factor for lung cancer.
- Subjects :
- Adult
Aged
Aged, 80 and over
Antigens, CD34 analysis
Disease-Free Survival
Female
Humans
Immunohistochemistry
Kaplan-Meier Estimate
Ki-67 Antigen analysis
Lung Neoplasms chemistry
Lung Neoplasms mortality
Lung Neoplasms therapy
Lymphatic Metastasis
Male
Middle Aged
Multimodal Imaging methods
Multivariate Analysis
Neoplasm Grading
Neoplasm Invasiveness
Neoplasm Staging
Positron-Emission Tomography
Predictive Value of Tests
Pressure
Proportional Hazards Models
Prospective Studies
Risk Factors
Time Factors
Tomography, X-Ray Computed
Treatment Outcome
Tumor Burden
Extracellular Fluid
Lung Neoplasms pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2186-1005
- Volume :
- 21
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia
- Publication Type :
- Academic Journal
- Accession number :
- 25641031
- Full Text :
- https://doi.org/10.5761/atcs.oa.14-00208