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History and present state of targeted intrathecal drug delivery.
- Source :
-
Current pain and headache reports [Curr Pain Headache Rep] 2015; Vol. 19 (2), pp. 474. - Publication Year :
- 2015
-
Abstract
- Nearly 50 years ago, the seminal experiments of Melzack and Wall, culminating in the gate control theory, coupled with the discovery of endogenous opioid receptors, helped shape modern understandings of pain and provided interventionalists a potent therapeutic gateway to neuraxial analgesia. This paper emphasizes the historical antecedents, present state, and emerging future of the neuromodulatory technique of targeted intrathecal drug delivery (TIDD) for chronic pain. The strengths of TIDD are its customizability, reversibility, programmability, and low risk profile. Its benefits are evidenced by improved pain relief and quality of life and reduced demand for health-care resources.
- Subjects :
- Analgesics, Opioid history
Chronic Pain etiology
Chronic Pain psychology
Drug Delivery Systems history
History, 20th Century
History, 21st Century
Humans
Infusion Pumps, Implantable history
Injections, Spinal history
Pain Measurement
Pain, Intractable etiology
Pain, Intractable psychology
Treatment Outcome
Analgesics, Opioid administration & dosage
Chronic Pain drug therapy
Injections, Spinal methods
Neoplasms complications
Pain, Intractable drug therapy
Quality of Life
Subjects
Details
- Language :
- English
- ISSN :
- 1534-3081
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Current pain and headache reports
- Publication Type :
- Academic Journal
- Accession number :
- 25638694
- Full Text :
- https://doi.org/10.1007/s11916-014-0474-8