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MAGI2/S-SCAM outside brain.
- Source :
-
Journal of biochemistry [J Biochem] 2015 Apr; Vol. 157 (4), pp. 177-84. Date of Electronic Publication: 2015 Jan 29. - Publication Year :
- 2015
-
Abstract
- Membrane-associated guanylate kinase with an inverted arrangement of protein-protein interaction domains (MAGI)2 (also called synaptic scaffolding molecule (S-SCAM), atrophin-1-interacting protein 1, activin receptor-interacting protein 1) is a scaffold protein that binds a wide variety of receptors, cell adhesion molecules and signalling molecules. It also interacts with other scaffold proteins and adaptors, and forms a protein network that supports cell junctions. As it is highly expressed in brain, the study on its roles in synaptic organization initially preceded. However, mounting evidence indicates that MAGI2/S-SCAM functions as a tumour suppressor and plays essential roles to maintain the integrity of cell structures in non-neuronal tissues. We review the articles regarding to MAGI2/S-SCAM outside brain and discuss future perspectives for the research of MAGI family proteins.<br /> (© The Authors 2015. Published by Oxford University Press on behalf of the Japanese Biochemical Society. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1756-2651
- Volume :
- 157
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of biochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25637633
- Full Text :
- https://doi.org/10.1093/jb/mvv009