HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients.

Authors :: Gianotti N
Canducci F
Galli L
Cossarini F
Salpietro S
Poli A
Nozza S
Spagnuolo V
Clementi M
Sampaolo M
Ceresola ER
Racca S
Lazzarin A
Castagna A
Source :: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases [Clin Microbiol Infect] 2015 Jan; Vol. 21 (1), pp. 103.e7-103.e10. Date of Electronic Publication: 2014 Oct 13.
Publication Year :: 2015
Abstract: In this single-centre, retrospective study, we analyzed data of 194 patients receiving antiretroviral therapy with <50 human immunodeficiency virus (HIV) RNA copies/mL in plasma and 318 HIV RNA/DNA paired samples. By kinetic polymerase chain reaction (kPCR) molecular system analysis, 104 (54%) subjects had undetectable HIV RNA and 90 (46%) had residual viraemia. Median (interquartile range) HIV DNA load was 780 (380-1930) copies/10(6) peripheral blood lymphocytes (PBL), and HIV DNA loads were independently associated with residual viraemia (p 0.002). Virological rebound occurred in 29/194 (15%) patients over a median (interquartile range) follow-up of 17.5 (13.5-31.5) months. Residual viraemia (p 0.002), but not HIV DNA load, was independently associated with virological rebound.<br /> (Copyright © 2014 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.)

Language :: English
ISSN :: 1469-0691
Volume :: 21
Issue :: 1
Database :: MEDLINE
Journal :: Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases
Publication Type :: Academic Journal
Accession number :: 25636935
Full Text :: https://doi.org/10.1016/j.cmi.2014.08.004

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