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Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice.

Authors :
Hwang MW
Ahn TS
Hong NR
Jeong HS
Jung MH
Ha KT
Kim BJ
Source :
World journal of gastroenterology [World J Gastroenterol] 2015 Jan 28; Vol. 21 (4), pp. 1117-24.
Publication Year :
2015

Abstract

Aim: To investigate the effects of San-Huang-Xie-Xin-Tang (SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal (GI) motility in mice.<br />Methods: The in vivo effects of SHXXT on GI motility were investigated by measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).<br />Results: In normal ICR mice, ITRs were significantly and dose-dependently increased by SHXXT (0.1-1 g/kg). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. The ITRs of GMD mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by SHXXT (0.1-1 g/kg).<br />Conclusion: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD.

Details

Language :
English
ISSN :
2219-2840
Volume :
21
Issue :
4
Database :
MEDLINE
Journal :
World journal of gastroenterology
Publication Type :
Academic Journal
Accession number :
25632184
Full Text :
https://doi.org/10.3748/wjg.v21.i4.1117