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Effects of traditional Chinese herbal medicine San-Huang-Xie-Xin-Tang on gastrointestinal motility in mice.
- Source :
-
World journal of gastroenterology [World J Gastroenterol] 2015 Jan 28; Vol. 21 (4), pp. 1117-24. - Publication Year :
- 2015
-
Abstract
- Aim: To investigate the effects of San-Huang-Xie-Xin-Tang (SHXXT), a herbal product used in traditional Chinese medicine, on gastrointestinal (GI) motility in mice.<br />Methods: The in vivo effects of SHXXT on GI motility were investigated by measuring the intestinal transit rates (ITRs) using Evans blue in normal mice and in mice with experimentally induced GI motility dysfunction (GMD).<br />Results: In normal ICR mice, ITRs were significantly and dose-dependently increased by SHXXT (0.1-1 g/kg). GMD was induced by injecting acetic acid or streptozotocin intraperitoneally. The ITRs of GMD mice were significantly reduced compared to normal mice, and these reductions were significantly and dose-dependently inhibited by SHXXT (0.1-1 g/kg).<br />Conclusion: These results suggest that SHXXT is a novel candidate for the development of a prokinetic agent that may prevent or alleviate GMD.
- Subjects :
- Acetic Acid
Animals
Disease Models, Animal
Dose-Response Relationship, Drug
Gastrointestinal Diseases chemically induced
Gastrointestinal Diseases physiopathology
Male
Mice, Inbred ICR
Streptozocin
Time Factors
Drugs, Chinese Herbal pharmacology
Gastrointestinal Agents pharmacology
Gastrointestinal Diseases drug therapy
Gastrointestinal Motility drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 2219-2840
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- World journal of gastroenterology
- Publication Type :
- Academic Journal
- Accession number :
- 25632184
- Full Text :
- https://doi.org/10.3748/wjg.v21.i4.1117