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Effect of a Natural Supplement Containing Curcuma Longa, Guggul, and Chlorogenic Acid in Patients With Metabolic Syndrome.
- Source :
-
Angiology [Angiology] 2015 Oct; Vol. 66 (9), pp. 856-61. Date of Electronic Publication: 2015 Jan 27. - Publication Year :
- 2015
-
Abstract
- The impact of a natural supplement (Kepar; Rikrea, Italy), containing several plant extracts such as curcuma longa, silymarin, guggul, chlorogenic acid, and inulin, was evaluated in 78 patients with metabolic syndrome (MetS; 45 men; age: 62 ± 9 years). Kepar at a dose of 2 pills/d was given for 4 months as add-on therapy to the ongoing treatment, maintained at fixed doses for the entire study. Anthropometric variables, plasma lipids, glucose parameters, and oxidative stress were measured at baseline and after 4 months. We found significant reductions in body weight (from 81.1 ± 13.5 to 79.4 ± 12.5 kg, P < .0001), body mass index (from 29.6 [23.7] to 29.3 [21.9] kg/m(2), P = .001), and waist circumference (from 105 ± 11 to 102 ± 10 cm, P = .0004) as well as in fasting glucose (from 6.5 [11.7] to 6.4 [7.6] mmol/L, P = .014) and total cholesterol (from 4.8 ± 1.4 to 4.5 ± 1.0 mmol/L, P = .03). No significant changes were found in the other appraised parameters, including oxidative stress. In conclusion, after few months of treatment Kepar seems to exert beneficial effects in patients with MetS. Larger studies with a longer follow-up period are needed to confirm these preliminary findings.<br /> (© The Author(s) 2015.)
- Subjects :
- Aged
Biomarkers blood
Blood Glucose drug effects
Blood Glucose metabolism
Chlorogenic Acid adverse effects
Cholesterol blood
Commiphora
Female
Humans
Inulin adverse effects
Italy
Male
Metabolic Syndrome blood
Metabolic Syndrome diagnosis
Metabolic Syndrome physiopathology
Middle Aged
Oxidative Stress drug effects
Phytotherapy
Pilot Projects
Plant Extracts adverse effects
Plant Gums adverse effects
Plants, Medicinal
Silymarin adverse effects
Time Factors
Treatment Outcome
Weight Loss drug effects
Chlorogenic Acid therapeutic use
Curcuma
Dietary Supplements adverse effects
Inulin therapeutic use
Metabolic Syndrome drug therapy
Plant Extracts therapeutic use
Plant Gums therapeutic use
Silymarin therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1940-1574
- Volume :
- 66
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 25632052
- Full Text :
- https://doi.org/10.1177/0003319714568792