Back to Search
Start Over
Glomerular Density in Biopsy-Proven Hypertensive Nephrosclerosis.
- Source :
-
American journal of hypertension [Am J Hypertens] 2015 Sep; Vol. 28 (9), pp. 1164-71. Date of Electronic Publication: 2015 Jan 27. - Publication Year :
- 2015
-
Abstract
- Background: Previous autopsy studies suggested that a reduced nephron number is associated with increased risk of hypertension and chronic kidney disease. However, the significance of the nephron number estimated from a renal biopsy in patients with hypertensive nephrosclerosis (HNS) has not yet been elucidated.<br />Methods: In this cross-sectional study, we examined the clinicopathological findings of biopsy-proven HNS patients with preserved renal function (estimated glomerular filtration rate ≥ 60 ml/min/1.73 m(2)). The glomerular density (GD; the number of glomeruli per total renal cortical area) in biopsy specimens was evaluated as a surrogate of the nephron number. Renal biopsies from kidney transplant donors were used as healthy controls.<br />Results: A total of 58 HNS patients were enrolled. The GD value in the HNS patients was low compared with those in the kidney transplant donors (2.0 vs. 3.2 /mm(2)). These differences remained significant when globally sclerotic glomeruli were included in the calculation of the GD. Of note, the GD in HNS patients with overt proteinuria (≥1 g/day) was significantly lower than that of HNS patients with mild proteinuria (<1g/day; 1.8 vs. 2.2/mm(2), P = 0.014). In contrast, other histopathological parameters, including the severity of global glomerulosclerosis, interstitial fibrosis/tubular atrophy and arterial and arteriole lesions were comparable between the 2 HNS subgroups. In addition, the GD was identified as a factor that was associated with the amount of urinary protein excretion at biopsy, independent of other clinicopathological factors.<br />Conclusions: These results suggest that a low GD is a renal histological characteristic of HNS patients, especially those with overt proteinuria.<br /> (© American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Adult
Aged
Biopsy
Cross-Sectional Studies
Female
Glomerular Filtration Rate
Humans
Hypertension diagnosis
Kidney Glomerulus physiopathology
Linear Models
Male
Middle Aged
Multivariate Analysis
Nephrosclerosis physiopathology
Predictive Value of Tests
Proteinuria etiology
Proteinuria pathology
Retrospective Studies
Risk Factors
Young Adult
Hypertension complications
Kidney Glomerulus pathology
Nephrosclerosis etiology
Nephrosclerosis pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1941-7225
- Volume :
- 28
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- American journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 25631380
- Full Text :
- https://doi.org/10.1093/ajh/hpu267