Back to Search
Start Over
Annotation of proteins of unknown function: initial enzyme results.
- Source :
-
Journal of structural and functional genomics [J Struct Funct Genomics] 2015 Mar; Vol. 16 (1), pp. 43-54. Date of Electronic Publication: 2015 Jan 29. - Publication Year :
- 2015
-
Abstract
- Working with a combination of ProMOL (a plugin for PyMOL that searches a library of enzymatic motifs for local structural homologs), BLAST and Pfam (servers that identify global sequence homologs), and Dali (a server that identifies global structural homologs), we have begun the process of assigning functional annotations to the approximately 3,500 structures in the Protein Data Bank that are currently classified as having "unknown function". Using a limited template library of 388 motifs, over 500 promising in silico matches have been identified by ProMOL, among which 65 exceptionally good matches have been identified. The characteristics of the exceptionally good matches are discussed.
- Subjects :
- Algorithms
Amino Acid Motifs genetics
Amino Acid Sequence
Binding Sites genetics
Computer Simulation
Models, Molecular
Molecular Sequence Data
Protein Binding
Protein Structure, Tertiary
Proteins genetics
Proteins metabolism
Reproducibility of Results
Sequence Homology, Amino Acid
Computational Biology methods
Databases, Protein
Molecular Sequence Annotation methods
Proteins chemistry
Software
Subjects
Details
- Language :
- English
- ISSN :
- 1570-0267
- Volume :
- 16
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of structural and functional genomics
- Publication Type :
- Academic Journal
- Accession number :
- 25630330
- Full Text :
- https://doi.org/10.1007/s10969-015-9194-5