Back to Search
Start Over
Elevated plasma YKL-40, lipids and lipoproteins, and ischemic vascular disease in the general population.
- Source :
-
Stroke [Stroke] 2015 Feb; Vol. 46 (2), pp. 329-35. - Publication Year :
- 2015
-
Abstract
- Background and Purpose: We tested the hypothesis that observationally and genetically elevated YKL-40 is associated with elevated lipids and lipoproteins and with increased risk of ischemic vascular disease.<br />Methods: We conducted cohort and Mendelian randomization studies in 96 110 individuals from the Danish general population, with measured plasma levels of YKL-40 (n=21 647), plasma lipids and lipoproteins (n=94 461), and CHI3L1 rs4950928 genotype (n=94 579).<br />Results: From 1977 to 2013, 3256 individuals developed ischemic stroke, 5629 ischemic cerebrovascular disease, 4183 myocardial infarction, and 10 271 developed ischemic heart disease. The 91% to 100% versus 0% to 33% YKL-40 percentile category was associated with a 34% increase in triglycerides, but only with minor changes in other lipids and lipoproteins. For these categories, the multifactorially adjusted hazard ratio was 1.99 (95% confidence interval, 1.49-2.67) for ischemic stroke, 1.85 (1.44-2.37) for ischemic cerebrovascular disease, 1.28 (0.95-1.73) for myocardial infarction, and 1.23 (1.01-1.51) for ischemic heart disease. When compared with rs4950928 CC homozygosity, the presence of G-allele was associated with a doubling (GC) or tripling (GG) in YKL-40 levels, but not with triglyceride levels or with risk of ischemic vascular disease. A doubling in YKL-40 was associated with a multifactorially adjusted observational hazard ratio for ischemic stroke of 1.18 (1.11-1.27), and a genetic odds ratio of 1.04 (0.95-1.15). Corresponding risk estimates were 1.15 (1.09-1.22) observationally and 1.06 (0.99-1.14) genetically for ischemic cerebrovascular disease, 1.08 (1.00-1.15) observationally and 1.04 (0.96-1.13) genetically for myocardial infarction, and 1.07 (1.02-1.12) observationally and 1.01 (0.96-1.07) genetically for ischemic heart disease.<br />Conclusions: Elevated YKL-40 was associated with a 34% increase in triglyceride levels and with a 2-fold increased risk of ischemic stroke, whereas genetically elevated YKL-40 were not.<br /> (© 2015 American Heart Association, Inc.)
- Subjects :
- Aged
Biomarkers blood
Cerebrovascular Disorders blood
Cerebrovascular Disorders diagnosis
Cerebrovascular Disorders epidemiology
Chitinase-3-Like Protein 1
Cohort Studies
Female
Humans
Lipids blood
Male
Middle Aged
Myocardial Infarction
Myocardial Ischemia diagnosis
Myocardial Ischemia epidemiology
Prospective Studies
Risk Factors
Stroke diagnosis
Stroke epidemiology
Vascular Diseases blood
Vascular Diseases diagnosis
Vascular Diseases epidemiology
Adipokines blood
Lectins blood
Lipoproteins blood
Myocardial Ischemia blood
Population Surveillance
Stroke blood
Triglycerides blood
Subjects
Details
- Language :
- English
- ISSN :
- 1524-4628
- Volume :
- 46
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Stroke
- Publication Type :
- Academic Journal
- Accession number :
- 25624368
- Full Text :
- https://doi.org/10.1161/STROKEAHA.114.007657