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Test-retest variability of adenosine A2A binding in the human brain with (11)C-TMSX and PET.
- Source :
-
EJNMMI research [EJNMMI Res] 2014 Dec 29; Vol. 4 (1), pp. 76. Date of Electronic Publication: 2014 Dec 29 (Print Publication: 2014). - Publication Year :
- 2014
-
Abstract
- Background: The goal of the present study was to evaluate the reproducibility of cerebral adenosine A2A receptor (A2AR) quantification using (11)C-TMSX and PET in a test-retest study.<br />Methods: Five healthy volunteers were studied twice. The test-retest variability was assessed for distribution volume (V T) and binding potential relative to non-displaceable uptake (BPND) based on either metabolite-corrected arterial blood sampling or a reference region. The cerebral cortex and centrum semiovale were used as candidate reference regions.<br />Results: Test-retest variability of V T was good in all regions (6% to 13%). In the putamen, BPND using the centrum semiovale displayed a lower test-retest variability (3%) than that of BPND using the cerebral cortex as a reference region (5%). The noninvasive method showed a higher or similar level of test-retest reproducibility compared to the invasive method.<br />Conclusions: Binding reproducibility is sufficient to use (11)C-TMSX as a tool to measure the change in A2AR in the human brain.
Details
- Language :
- English
- ISSN :
- 2191-219X
- Volume :
- 4
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- EJNMMI research
- Publication Type :
- Academic Journal
- Accession number :
- 25621197
- Full Text :
- https://doi.org/10.1186/s13550-014-0076-9