Back to Search
Start Over
Disease-specific alterations in the enteric virome in inflammatory bowel disease.
- Source :
-
Cell [Cell] 2015 Jan 29; Vol. 160 (3), pp. 447-60. Date of Electronic Publication: 2015 Jan 22. - Publication Year :
- 2015
-
Abstract
- Decreases in the diversity of enteric bacterial populations are observed in patients with Crohn's disease (CD) and ulcerative colitis (UC). Less is known about the virome in these diseases. We show that the enteric virome is abnormal in CD and UC patients. In-depth analysis of preparations enriched for free virions in the intestine revealed that CD and UC were associated with a significant expansion of Caudovirales bacteriophages. The viromes of CD and UC patients were disease and cohort specific. Importantly, it did not appear that expansion and diversification of the enteric virome was secondary to changes in bacterial populations. These data support a model in which changes in the virome may contribute to intestinal inflammation and bacterial dysbiosis. We conclude that the virome is a candidate for contributing to, or being a biomarker for, human inflammatory bowel disease and speculate that the enteric virome may play a role in other diseases.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Bacteria classification
Bacteria genetics
Bacteria isolation & purification
Case-Control Studies
Caudovirales genetics
Cohort Studies
Colitis, Ulcerative microbiology
Colitis, Ulcerative pathology
Colitis, Ulcerative therapy
Crohn Disease microbiology
Crohn Disease pathology
Crohn Disease therapy
Dysbiosis microbiology
Dysbiosis pathology
Dysbiosis therapy
Feces microbiology
Feces virology
Humans
Metagenome
Microviridae genetics
Caudovirales isolation & purification
Colitis, Ulcerative virology
Crohn Disease virology
Dysbiosis virology
Microviridae isolation & purification
Subjects
Details
- Language :
- English
- ISSN :
- 1097-4172
- Volume :
- 160
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Cell
- Publication Type :
- Academic Journal
- Accession number :
- 25619688
- Full Text :
- https://doi.org/10.1016/j.cell.2015.01.002