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Rapamycin Versus Intermittent Feeding: Dissociable Effects on Physiological and Behavioral Outcomes When Initiated Early and Late in Life.
- Source :
-
The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2016 Jul; Vol. 71 (7), pp. 866-75. Date of Electronic Publication: 2015 Jan 23. - Publication Year :
- 2016
-
Abstract
- Rapamycin, an inhibitor of the mammalian target of rapamycin pathway, has been shown to increase mammalian life span; less is known concerning its effect on healthspan. The primary aim of this study was to examine rapamycin's role in the alteration of several physiological and behavioral outcomes compared with the healthspan-inducing effects of intermittent feeding (IF), another life-span-enhancing intervention. Male Fisher 344 × Brown Norway rats (6 and 25 months of age) were treated with rapamycin or IF for 5 weeks. IF and rapamycin reduced food consumption and body weight. Rapamycin increased relative lean mass and decreased fat mass. IF failed to alter fat mass but lowered relative lean mass. Behaviorally, rapamycin resulted in high activity levels in old animals, IF increased levels of "anxiety" for both ages, and grip strength was not significantly altered by either treatment. Rapamycin, not IF, decreased circulating leptin in older animals to the level of young animals. Glucose levels were unchanged with age or treatment. Hypothalamic AMPK and pAMPK levels decreased in both older treated groups. This pattern of results suggests that rapamycin has more selective and healthspan-inducing effects when initiated late in life.<br /> (© The Author 2015. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.)
- Subjects :
- AMP-Activated Protein Kinases metabolism
Animals
Feeding Methods psychology
Immunosuppressive Agents metabolism
Immunosuppressive Agents pharmacology
Leptin metabolism
Male
Physical Conditioning, Animal methods
Rats
TOR Serine-Threonine Kinases metabolism
Treatment Outcome
Aging drug effects
Aging physiology
Aging psychology
Behavior, Animal drug effects
Behavior, Animal physiology
Longevity drug effects
Longevity physiology
Signal Transduction drug effects
Signal Transduction physiology
Sirolimus metabolism
Sirolimus pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1758-535X
- Volume :
- 71
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- The journals of gerontology. Series A, Biological sciences and medical sciences
- Publication Type :
- Academic Journal
- Accession number :
- 25617380
- Full Text :
- https://doi.org/10.1093/gerona/glu238