Back to Search
Start Over
Single blind, randomized, controlled trial of a lightening product with and without iontophoresis versus tretinoin and vehicle for hyperpigmentation.
- Source :
-
Journal of drugs in dermatology : JDD [J Drugs Dermatol] 2015 Jan; Vol. 14 (1), pp. 13-8. - Publication Year :
- 2015
-
Abstract
- Background: Hyperpigmentation is a common concern and has many causes including lentigines and melasma. Currently available topical products for hyperpigmentation are limited by their potential for irritation, lack of demonstrated efficacy or regulatory concerns.<br />Objective: To compare the efficacy of a new skin lightening product with and without iontophoresis to a known effective product (tretinoin) and placebo on hyperpigmentation caused by lentigines and/or melasma. Secondary objectives included an assessment of the product's effects on the appearance of rhytides and roughness.<br />Methods and Materials: Eighty subjects were randomized into one of four treatment groups: proprietary lightening product, proprietary lightening product with iontophoresis, tretinoin 0.05% cream, or vehicle control. Seventy-four subjects completed all study visits. Blinded assessments of subjects were performed at each visit under ambient and Wood's light.<br />Results: The proprietary skin lightening product improved facial hyperpigmentation versus placebo under ambient light (P= 0.05) and Wood's lamp (P= 0.01) examination. Tretinoin also improved facial hyperpigmentation versus placebo under Wood's lamp (P= 0.01). The proprietary product was better tolerated than tretinoin, with fewer subject reported side effects.<br />Conclusion: The investigational product was effective and may be better tolerated than tretinoin cream.
- Subjects :
- Adult
Dermatologic Agents administration & dosage
Dermatologic Agents adverse effects
Female
Humans
Lentigo drug therapy
Melanosis drug therapy
Middle Aged
Single-Blind Method
Skin Aging drug effects
Skin Lightening Preparations adverse effects
Treatment Outcome
Tretinoin adverse effects
Hyperpigmentation drug therapy
Iontophoresis methods
Skin Lightening Preparations administration & dosage
Tretinoin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1545-9616
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of drugs in dermatology : JDD
- Publication Type :
- Academic Journal
- Accession number :
- 25607903