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Effect of Salmonella typhimurium porins on biological activities of human polymorphonuclear leukocytes.
- Source :
-
Microbial pathogenesis [Microb Pathog] 1989 Nov; Vol. 7 (5), pp. 337-46. - Publication Year :
- 1989
-
Abstract
- The effect of Salmonella typhimurium porins on human polymorphonuclear leukocytes (PMNs) was studied. Labeled porins were shown to bind to the PMNs, and could be completely displaced by unlabeled porins. The binding caused modifications of membrane integrity and of the physico-chemical characteristics of the PMN surface, e.g. decreased oxidative burst, decreased hydrophobicity and altered cell morphology. The porins acted as both chemotaxins and chemotaxinogens. When PMNs were preincubated with porins their migration in the presence of commonly used chemoattractants (serum activated by zymosan or N-formyl-L-methionyl-L-leucyl-L-phenylalanine) was inhibited.
- Subjects :
- Bacterial Outer Membrane Proteins metabolism
Cell Membrane ultrastructure
Cells, Cultured
Chemotaxis, Leukocyte
Humans
Kinetics
Macrophage-1 Antigen
Neutrophils metabolism
Neutrophils ultrastructure
Porins
Receptors, Complement metabolism
Receptors, Fc metabolism
Bacterial Outer Membrane Proteins pharmacology
Neutrophils drug effects
Salmonella typhimurium metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 0882-4010
- Volume :
- 7
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Microbial pathogenesis
- Publication Type :
- Academic Journal
- Accession number :
- 2560111
- Full Text :
- https://doi.org/10.1016/0882-4010(89)90037-5