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Anti-sulfatide IgM antibodies in peripheral neuropathy: to test or not to test?
- Source :
-
European journal of neurology [Eur J Neurol] 2015 May; Vol. 22 (5), pp. 879-82. Date of Electronic Publication: 2015 Jan 18. - Publication Year :
- 2015
-
Abstract
- Background and Purpose: Anti-sulfatide immunoglobulin M (IgM) antibodies have been associated with different forms of neuropathies but their diagnostic role in neuropathy remains unclear.<br />Methods: The clinical association of increased titers of anti-sulfatide IgM antibodies in 570 patients with neuropathy and related disorders examined in our laboratory since 2004 was reviewed. Sera were tested by enzyme-linked immunosorbent assay at the initial serum dilution of 1:32,000 and titrated by serial two-fold dilution. In all positive patients IgM antibodies to myelin-associated glycoprotein (MAG) were also measured by western blot.<br />Results: High titers of anti-sulfatide antibodies were found in 39 patients including 33 (85%) who also had anti-MAG IgM. Six patients did not have anti-MAG IgM including five in whom moderately increased anti-sulfatide titers were associated with different forms of neuropathy. One patient with a demyelinating neuropathy and IgM monoclonal gammopathy had markedly increased anti-sulfatide titers (1:256,000).<br />Conclusions: Increased titers of anti-sulfatide IgM antibodies are not infrequent in patients with neuropathy where they are often associated with a concomitant reactivity to MAG. A selective reactivity to sulfatide, however, is rarely found and is associated with different forms of neuropathy limiting its usefulness in the diagnosis of neuropathy.<br /> (© 2015 EAN.)
Details
- Language :
- English
- ISSN :
- 1468-1331
- Volume :
- 22
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- European journal of neurology
- Publication Type :
- Academic Journal
- Accession number :
- 25597226
- Full Text :
- https://doi.org/10.1111/ene.12658