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Genetic variants are not associated with outcome in patients with coronary artery disease and left ventricular dysfunction: results of the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.
- Source :
-
Cardiology [Cardiology] 2015; Vol. 130 (2), pp. 69-81. Date of Electronic Publication: 2015 Jan 13. - Publication Year :
- 2015
-
Abstract
- Objectives and Background: We evaluated the ability of 23 genetic variants to provide prognostic information in patients enrolled in the Genetic Substudy of the Surgical Treatment for Ischemic Heart Failure (STICH) trials.<br />Methods: Patients assigned to STICH Hypothesis 1 were randomized to medical therapy with or without coronary artery bypass grafting (CABG). Those assigned to STICH Hypothesis 2 were randomized to CABG or CABG with left ventricular reconstruction.<br />Results: In patients assigned to STICH Hypothesis 2 (n = 714), no genetic variant met the prespecified Bonferroni-adjusted threshold for statistical significance (p < 0.002); however, several variants met nominal prognostic significance: variants in the β2-adrenergic receptor gene (β2-AR Gln27Glu) and in the A1-adenosine receptor gene (A1-717 T/G) were associated with an increased risk of a subject dying or being hospitalized for a cardiac problem (p = 0.027 and 0.031, respectively). These relationships remained nominally significant even after multivariable adjustment for prognostic clinical variables. However, none of the 23 genetic variants influenced all-cause mortality or the combination of death or cardiovascular hospitalization in the STICH Hypothesis 1 population (n = 532) by either univariate or multivariable analysis.<br />Conclusion: We were unable to identify the predictive genotypes in optimally treated patients in these two ischemic heart failure populations.
- Subjects :
- Aged
Cohort Studies
Coronary Artery Bypass methods
Female
Genetic Markers
Heart Failure mortality
Hospitalization
Humans
Male
Middle Aged
Multivariate Analysis
Prognosis
Risk Factors
Treatment Outcome
Coronary Artery Disease genetics
Genotype
Heart Failure genetics
Receptor, Adenosine A1 genetics
Receptors, Adrenergic, beta-2 genetics
Ventricular Dysfunction, Left genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9751
- Volume :
- 130
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 25592552
- Full Text :
- https://doi.org/10.1159/000368221