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Germ cell-specific Atg7 knockout results in primary ovarian insufficiency in female mice.
- Source :
-
Cell death & disease [Cell Death Dis] 2015 Jan 15; Vol. 6, pp. e1589. Date of Electronic Publication: 2015 Jan 15. - Publication Year :
- 2015
-
Abstract
- Primary ovarian insufficiency (POI) is a common cause of infertility in around 1-2% of women aged <40 years. However, the mechanisms that cause POI are still poorly understood. Here we showed that germ cell-specific knockout of an essential autophagy induction gene Atg7 led to subfertility in female mice. The subfertility of Atg7 deletion females was caused by severe ovarian follicle loss, which is very similar to human POI patients. Further investigation revealed that germ cell-specific Atg7 knockout resulted in germ cell over-loss at the neonatal transition period. In addition, our in vitro studies also demonstrated that autophagy could protect oocytes from over-loss by apoptosis in neonatal ovaries under the starvation condition. Taken together, our results uncover a new role for autophagy in the regulation of ovarian primordial follicle reservation and hint that autophagy-related genes might be potential pathogenic genes to POI of women.
- Subjects :
- Animals
Animals, Newborn
Apoptosis
Autophagy
Autophagy-Related Protein 7
Cell Count
Female
Fetus pathology
Gene Deletion
Humans
Infertility, Female metabolism
Infertility, Female pathology
Mice
Mice, Knockout
Microtubule-Associated Proteins metabolism
Oocytes metabolism
Oocytes pathology
Organ Specificity
Ovarian Follicle embryology
Ovarian Follicle pathology
Ovum pathology
Microtubule-Associated Proteins deficiency
Ovum metabolism
Primary Ovarian Insufficiency metabolism
Primary Ovarian Insufficiency pathology
Subjects
Details
- Language :
- English
- ISSN :
- 2041-4889
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Cell death & disease
- Publication Type :
- Academic Journal
- Accession number :
- 25590799
- Full Text :
- https://doi.org/10.1038/cddis.2014.559