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Gut Bacteria Products Prevent AKI Induced by Ischemia-Reperfusion.
- Source :
-
Journal of the American Society of Nephrology : JASN [J Am Soc Nephrol] 2015 Aug; Vol. 26 (8), pp. 1877-88. Date of Electronic Publication: 2015 Jan 14. - Publication Year :
- 2015
-
Abstract
- Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal microbiota and have anti-inflammatory and histone deacetylase-inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis. However, it was also associated with an increase in autophagy. Moreover, SCFAs inhibited histone deacetylase activity and modulated the expression levels of enzymes involved in chromatin modification. In vitro analyses showed that SCFAs modulated the inflammatory process, decreasing the maturation of dendritic cells and inhibiting the capacity of these cells to induce CD4(+) and CD8(+) T cell proliferation. Furthermore, SCFAs ameliorated the effects of hypoxia in kidney epithelial cells by improving mitochondrial biogenesis. Notably, mice treated with acetate-producing bacteria also had better outcomes after AKI. Thus, we demonstrate that SCFAs improve organ function and viability after an injury through modulation of the inflammatory process, most likely via epigenetic modification.<br /> (Copyright © 2015 by the American Society of Nephrology.)
- Subjects :
- Acute Kidney Injury metabolism
Animals
Bifidobacterium
Cell Line
Dendritic Cells metabolism
Drug Evaluation, Preclinical
Inflammation drug therapy
Male
Mice, Inbred C57BL
Oxidative Stress
Probiotics therapeutic use
Reperfusion Injury metabolism
Acute Kidney Injury prevention & control
Fatty Acids, Volatile therapeutic use
Reperfusion Injury prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 1533-3450
- Volume :
- 26
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Journal of the American Society of Nephrology : JASN
- Publication Type :
- Academic Journal
- Accession number :
- 25589612
- Full Text :
- https://doi.org/10.1681/ASN.2014030288