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Are climacteric complaints associated with risk factors of cardiovascular disease in peri-menopausal women?
- Source :
-
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology [Gynecol Endocrinol] 2015 May; Vol. 31 (5), pp. 359-62. Date of Electronic Publication: 2015 Jan 14. - Publication Year :
- 2015
-
Abstract
- Recent studies indicate that metabolic risk for cardiovascular disease is increased in post-menopausal women suffering from disturbances, such as hot flushes. In order to evaluate whether this is also true in peri-menopausal women, we performed an observational study on 590 peri-menopausal women of an outpatient center at a University Hospital. Each cardiovascular risk factor, such as blood pressure, fasting glucose, fasting lipids and the 10-year risk for cardiovascular disease was tested for its relation to climacteric complaints. Greene's climacteric scale, and its subscales were used to evaluate climacteric symptoms. Analyses were corrected for confounders derived by personal history and anthropometric measures. When corrected for confounders, Greene's score was a positive determinant of triglycerides (R(2 )= 0.249; p = 0.0001), triglycerides/HDL-cholesterol (R(2 )= 0.316; p = 0.0001), glucose (R(2 )= 0.101; p = 0.0003), and the 10-year risk for cardiovascular disease, calculated by the Framingham formula (R(2 )= 0.081; p = 0.0001). Greene's vasomotor sub-score was an independent determinant of LDL-cholesterol (R(2 )= 0.025; p = 0.01), and LDL/HDL-cholesterol (R(2 )= 0.143; p = 0.0001), while Greene's depression sub-score was a negative determinant of HDL-cholesterol (R(2 )= 0.179; p = 0.0001). The data also indicate that in peri-menopausal women, menopausal symptoms evaluated by a validated climacteric scale are associated with biochemical risk factors for atherosclerosis and cardiovascular disease.
- Subjects :
- Blood Glucose metabolism
Blood Pressure
Body Mass Index
Cardiovascular Diseases blood
Cholesterol, HDL blood
Cholesterol, LDL blood
Cohort Studies
Diabetes Mellitus blood
Dyslipidemias blood
Female
Humans
Middle Aged
Regression Analysis
Retrospective Studies
Risk Factors
Triglycerides blood
Waist-Hip Ratio
Cardiovascular Diseases epidemiology
Diabetes Mellitus epidemiology
Dyslipidemias epidemiology
Hot Flashes epidemiology
Hypertension epidemiology
Perimenopause blood
Sweating
Subjects
Details
- Language :
- English
- ISSN :
- 1473-0766
- Volume :
- 31
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology
- Publication Type :
- Academic Journal
- Accession number :
- 25585548
- Full Text :
- https://doi.org/10.3109/09513590.2014.998188