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Chemotherapy-induced premature ovarian failure: mechanisms and prevention.
- Source :
-
Steroids [Steroids] 1989 Dec; Vol. 54 (6), pp. 607-26. - Publication Year :
- 1989
-
Abstract
- Significant advances have been made in the previously unexplored areas of the mechanisms involved in cyclophosphamide (CTX)-induced ovarian toxicity and the protective effects of luteinizing hormone-releasing hormone (LHRH agonists. The structure and function of granulosa cells and oocytes are affected by the chemotherapeutic agent, CTX. Results of experiments in female rats indicate that LHRH agonists may protect the ovaries from the toxic effects of chemotherapy. The protective effect may be related to the inhibition of ovarian mitotic activity during LHRH agonist administration. This inhibition is much more pronounced in female compared to male rats. This may be related to the observed better gonadal protective effects in females compared to males. Further experiments are underway to determine whether similar protective effects occur in female primates.
- Subjects :
- Animals
Cyclophosphamide analogs & derivatives
Cyclophosphamide antagonists & inhibitors
Female
Granulosa Cells drug effects
Humans
In Vitro Techniques
Macaca mulatta
Male
Ovarian Diseases prevention & control
Rats
Rats, Inbred Strains
Receptors, LHRH drug effects
Cyclophosphamide toxicity
Ovarian Diseases chemically induced
Subjects
Details
- Language :
- English
- ISSN :
- 0039-128X
- Volume :
- 54
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Steroids
- Publication Type :
- Academic Journal
- Accession number :
- 2558431
- Full Text :
- https://doi.org/10.1016/0039-128x(89)90084-6