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A yolk-like multifunctional platform for multimodal imaging and synergistic therapy triggered by a single near-infrared light.
- Source :
-
ACS nano [ACS Nano] 2015 Feb 24; Vol. 9 (2), pp. 1630-47. Date of Electronic Publication: 2015 Jan 15. - Publication Year :
- 2015
-
Abstract
- To integrate photodynamic therapy (PDT) with photothermal therapy (PTT) and chemotherapy for enhanced antitumor efficiency, we developed a mild and rational route to synthesize novel multifunctional GdOF:Ln@SiO2 (Ln = 10%Yb/1%Er/4%Mn) mesoporous capsules using strong up-conversion luminescent (UCL) GdOF:Ln as cores and mesoporous silica layer as shells, followed by modification with varied functional groups onto the framework. It was found that due to the codoped Yb/Er/Mn in GdOF, the markedly enhanced red emission can efficiently transfer energy to the conjugated PDT agent (ZnPc) which produces high singlet oxygen, and the incorporated carbon dots outside the shell can generate obvious thermal effect under 980 nm laser irradiation and also prevent the premature leaking of ZnPc. Simultaneously, the as-produced thermal effect can obviously enhance the doxorubicin (DOX) release, which greatly improves the chemotherapy, resulting in a synergistic therapeutic effect. The system exhibits drastically enhanced therapeutic efficiency against tumor growth, as demonstrated both in vitro and in vivo. Especially, the doped rare earth ions in the host endow the material with excellent UCL imaging, magnetic resonance imaging (MRI), and computed tomography (CT) imaging properties, thus realizing the target of multimodal imaging guided multiple therapies.
- Subjects :
- Animals
Carcinoma, Hepatocellular diagnosis
Carcinoma, Hepatocellular drug therapy
Carcinoma, Hepatocellular pathology
Cell Line
Cell Survival drug effects
Doxorubicin chemistry
Doxorubicin pharmacology
Doxorubicin therapeutic use
Drug Carriers adverse effects
Drug Liberation
Female
Gadolinium chemistry
HeLa Cells
Humans
Indoles chemistry
Indoles pharmacology
Indoles therapeutic use
Isoindoles
Liver Neoplasms diagnosis
Liver Neoplasms drug therapy
Liver Neoplasms pathology
Materials Testing
Mice
Nanoparticles chemistry
Organometallic Compounds chemistry
Organometallic Compounds pharmacology
Organometallic Compounds therapeutic use
Porosity
Zinc Compounds
Drug Carriers chemistry
Infrared Rays
Multimodal Imaging
Photochemotherapy
Silicon Dioxide chemistry
Theranostic Nanomedicine methods
Subjects
Details
- Language :
- English
- ISSN :
- 1936-086X
- Volume :
- 9
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- ACS nano
- Publication Type :
- Academic Journal
- Accession number :
- 25581331
- Full Text :
- https://doi.org/10.1021/nn5063613