Comparing the prognostic performance of ASSIST to interleukin-6 and procalcitonin in patients with severe sepsis or septic shock.

Authors :: Wong HR
Walley KR
Pettilä V
Meyer NJ
Russell JA
Karlsson S
Shashaty MG
Lindsell CJ
Source :: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2015 Mar; Vol. 20 (2), pp. 132-5. Date of Electronic Publication: 2015 Jan 12.
Publication Year :: 2015
Abstract: Context: We recently derived and validated a multi-biomarker-based model (ASSIST) to stratify patients with sepsis based on initial mortality risk.<br />Objective: The objective of this study was to compare the performance of ASSIST to interleukin-6 (IL6) and procalcitonin (PCT).<br />Methods: The area-under-the-receiver operating characteristic curve for predicting 28-d mortality using ASSIST was compared with that of IL6 (n = 452) and PCT (n = 235).<br />Results: The area under the curve for ASSIST was greater than that of IL6 and PCT.<br />Conclusions: ASSIST estimated the probability of mortality more reliably than IL6 and PCT in this cohort of patients with sepsis.

Language :: English
ISSN :: 1366-5804
Volume :: 20
Issue :: 2
Database :: MEDLINE
Journal :: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Publication Type :: Academic Journal
Accession number :: 25578228
Full Text :: https://doi.org/10.3109/1354750X.2014.1000971

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