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Low molecular weight heparin (Alfa LHWH) compared with unfractionated heparin in prevention of deep-vein thrombosis after hip fractures.
- Source :
-
International angiology : a journal of the International Union of Angiology [Int Angiol] 1989 Jul-Sep; Vol. 8 (3), pp. 134-9. - Publication Year :
- 1989
-
Abstract
- Efficacy and safety of a low molecular weight heparin (Alfa LMWH) was compared with unfractionated heparin (UFH) in the prevention of post-operative venous thromboembolism after hip fractures. Forty-nine patients were randomized to treatment with Alfa LMWH 7500 anti-Xa coagulometric units twice daily or with UFH 5000 IU t.i.d. Screening for thrombosis was performed with 125-I-fibrinogen leg scanning and strain-gauge plethysmography. Positive results were confirmed by venography. Five patients in the Alfa LMWH group (20 per cent) developed venographycally proven deep vein thrombosis (DVT) versus seven (29 per cent) in the UFH group. One pulmonary embolism and two deaths occurred in the UFH group and none in the LMWH group. No differences in haemorrhagic complications and blood loss indices were observed. Alfa LMWH appears to be a promising drug for prevention of venous thromboembolism after orthopaedic surgery. A "flexible" schedule of administration is proposed on the basis of the results of plasma anti-Xa assays.
- Subjects :
- Aged
Aged, 80 and over
Blood Coagulation Tests
Female
Heparin adverse effects
Heparin, Low-Molecular-Weight adverse effects
Humans
Male
Randomized Controlled Trials as Topic
Heparin administration & dosage
Heparin, Low-Molecular-Weight administration & dosage
Hip Fractures surgery
Postoperative Complications prevention & control
Thrombophlebitis prevention & control
Subjects
Details
- Language :
- English
- ISSN :
- 0392-9590
- Volume :
- 8
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- International angiology : a journal of the International Union of Angiology
- Publication Type :
- Academic Journal
- Accession number :
- 2556484