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Preventive effect of phytic acid on lysosomal hydrolases in normal and isoproterenol-induced myocardial infarction in Wistar rats.
- Source :
-
Toxicology mechanisms and methods [Toxicol Mech Methods] 2015 Feb; Vol. 25 (2), pp. 150-4. Date of Electronic Publication: 2015 Feb 17. - Publication Year :
- 2015
-
Abstract
- This study was aimed to evaluate the preventive role of phytic acid on lysosomal enzymes in isoproterenol (ISO)-induced myocardial infarction (MI) in male Wistar rats. Rats subcutaneously injected with ISO (85 mg/kg) at an interval of 24 h for two days showed a significant increase in the activities of lysosomal enzymes (glucuronidase, N-acetyl glucosaminidase, galactosidase, cathepsin-B and cathepsin-D) were increased significantly in serum and the heart of ISO-induced rats, but the activities of glucuronidase and cathepsin-D were decreased significantly in the lysosomal fraction of the heart. Pretreatment with phytic acid (25 and 50 mg/kg) daily for a period of 56 d positively altered activities of lysosomal hydrolases in ISO-induced rats. Thus, phytic acid possesses a cardioprotective effect in ISO-induced MI in rats.
- Subjects :
- Acetylglucosaminidase metabolism
Animals
Cathepsin B metabolism
Cathepsin D metabolism
Cytoprotection
Disease Models, Animal
Galactosidases metabolism
Glucuronidase metabolism
Lysosomes enzymology
Male
Myocardial Infarction chemically induced
Myocardial Infarction enzymology
Myocardial Infarction pathology
Myocytes, Cardiac enzymology
Myocytes, Cardiac pathology
Rats, Wistar
Time Factors
Antioxidants pharmacology
Hydrolases metabolism
Isoproterenol
Lysosomes drug effects
Myocardial Infarction prevention & control
Myocytes, Cardiac drug effects
Phytic Acid pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1537-6524
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Toxicology mechanisms and methods
- Publication Type :
- Academic Journal
- Accession number :
- 25560919
- Full Text :
- https://doi.org/10.3109/15376516.2014.1003421