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Sleep Duration, Kidney Function, and Their Effects on Cerebral Small Vessel Disease in Elderly Hypertensive Patients.
- Source :
-
American journal of hypertension [Am J Hypertens] 2015 Jul; Vol. 28 (7), pp. 884-93. Date of Electronic Publication: 2015 Jan 05. - Publication Year :
- 2015
-
Abstract
- Background: Short sleep duration has been shown to be associated with cardio/cerebrovascular disease. White matter hyperintensities (WMH) have been associated with an increased risk of stroke. In addition to high ambulatory blood pressure (BP), chronic kidney disease (CKD) is a risk for WMH. In this study, we investigated the relationships among sleep duration, CKD, and WMH in elderly hypertensives.<br />Methods: Ambulatory BP monitoring and brain magnetic resonance imaging were performed in 514 Japanese elderly hypertensives (mean age 72.3 years, males 37%). WMH cases were further divided into deep subcortical white matter lesion or periventricular hyperintensity (PVH). CKD (n = 193) was defined as estimated glomerular filtration rate less than 60 ml/min/1.73 m(2).<br />Results: According to sleep duration (<7.5, ≥7.5 to <9.5, and ≥9.5 hour per night), significant associations of sleep duration were observed with WMH and PVH. In the regression analysis including age, gender, smoking, antiplatelet agents use, 24-hour systolic BP, nondipper, white coat hypertension and CKD, short sleep duration was significantly positively associated with WMH and PVH when subjects with mid-range sleep duration were used as a reference group. A significant interaction was found between short sleep duration and CKD for PVH. In the non-CKD group, short sleep duration had strong significant positive associations with WMH and PVH.<br />Conclusions: In the present study, short sleep duration was a positive significant determinant for WMH and PVH in elderly hypertensives. Sleep duration might serve as a strong determinant for white matter lesions especially in those without CKD.<br /> (© American Journal of Hypertension, Ltd 2015. All rights reserved. For Permissions, please email: journals.permissions@oup.com.)
- Subjects :
- Age Factors
Aged
Aged, 80 and over
Blood Pressure
Blood Pressure Monitoring, Ambulatory
Cerebral Small Vessel Diseases diagnosis
Cerebral Small Vessel Diseases physiopathology
Female
Glomerular Filtration Rate
Humans
Hypertension diagnosis
Hypertension physiopathology
Japan
Leukoencephalopathies complications
Leukoencephalopathies diagnosis
Magnetic Resonance Imaging
Male
Middle Aged
Renal Insufficiency, Chronic diagnosis
Renal Insufficiency, Chronic physiopathology
Risk Factors
Time Factors
Cerebral Small Vessel Diseases etiology
Hypertension complications
Kidney physiopathology
Renal Insufficiency, Chronic complications
Sleep
Subjects
Details
- Language :
- English
- ISSN :
- 1941-7225
- Volume :
- 28
- Issue :
- 7
- Database :
- MEDLINE
- Journal :
- American journal of hypertension
- Publication Type :
- Academic Journal
- Accession number :
- 25559119
- Full Text :
- https://doi.org/10.1093/ajh/hpu243