NLRP1 L155H Polymorphism is a Risk Factor for Preeclampsia Development.

Authors :: Pontillo A
Reis EC
Bricher PN
Vianna P
Diniz S
Fernandes KS
Chies JA
Sandrim V
Source :: American journal of reproductive immunology (New York, N.Y. : 1989) [Am J Reprod Immunol] 2015 Jun; Vol. 73 (6), pp. 577-81. Date of Electronic Publication: 2014 Dec 29.
Publication Year :: 2015
Abstract: Problem: Augmented levels of IL-1ß have been pointed out as an important pathogenic factor for preeclampsia development. Inflammasome is the cytoplasmic complex responsible for pro-IL1ß cleavage and IL-1ß secretion. Aim of the study was to evaluate the association between polymorphisms in inflammasome' genes and preeclampsia.<br />Method of Study: Selected polymorphisms in inflammasome genes (NLRP1, NLRP3, CARD8, and IL1B) were analyzed in 286 Brazilian women with and 309 without preeclampsia.<br />Results and Conlclusions: The NLRP1 variant rs12150220 (L155H) was associated with the development of preeclampsia (OR = 1.58), suggesting a role of this inflammasome receptor in the pathogenesis of this multifactorial disorder.<br /> (© 2014 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)

Subjects :: Adaptor Proteins, Signal Transducing immunology
Adult
Apoptosis Regulatory Proteins immunology
Brazil
Female
Humans
Inflammasomes genetics
Inflammasomes immunology
NLR Proteins
Pre-Eclampsia immunology
Pregnancy
Risk Factors
Adaptor Proteins, Signal Transducing genetics
Apoptosis Regulatory Proteins genetics
Polymorphism, Single Nucleotide
Pre-Eclampsia genetics

Language :: English
ISSN :: 1600-0897
Volume :: 73
Issue :: 6
Database :: MEDLINE
Journal :: American journal of reproductive immunology (New York, N.Y. : 1989)
Publication Type :: Academic Journal
Accession number :: 25556596
Full Text :: https://doi.org/10.1111/aji.12353