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Effects of growth hormone-releasing hormone on visceral fat, metabolic, and cardiovascular indices in human studies.
- Source :
-
Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society [Growth Horm IGF Res] 2015 Apr; Vol. 25 (2), pp. 59-65. Date of Electronic Publication: 2014 Dec 20. - Publication Year :
- 2015
-
Abstract
- Increased visceral adipose tissue (VAT) is associated with reductions in endogenous GH secretion, possibly as a result of hyperinsulinemia, increased circulating free fatty acid, increased somatostatin tone, and reduced ghrelin. Reduced GH may, in turn, further exacerbate visceral fat accumulation because of decreased hormone-sensitive lipolysis in this depot. Data from multiple populations demonstrate that both reduced GH and increased VAT appear to contribute independently to dyslipidemia, increased systemic inflammation, and increased cardiovascular risk. The reductions in GH in states of visceral adiposity are characterized by reduced basal and pulsatile GH secretion with intact pulse frequency. Treatment with GH-releasing hormone (GHRH) provides a means to reverse these abnormalities, increasing endogenous basal and pulsatile GH secretion without altering pulse frequency. This review describes data from HIV-infected individuals and individuals with general obesity showing that treatment with GHRH significantly reduces visceral fat, ameliorates dyslipidemia, and reduces markers of cardiovascular risk. Further research is needed regarding the long-term efficacy and safety of this treatment modality.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Health Status Indicators
Human Growth Hormone metabolism
Humans
Insulin-Like Growth Factor I metabolism
Intra-Abdominal Fat metabolism
Intra-Abdominal Fat pathology
Obesity metabolism
Obesity pathology
Signal Transduction drug effects
Cardiovascular Diseases metabolism
Cardiovascular Diseases pathology
Growth Hormone-Releasing Hormone pharmacology
Intra-Abdominal Fat drug effects
Metabolic Diseases metabolism
Metabolic Diseases pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1532-2238
- Volume :
- 25
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society
- Publication Type :
- Academic Journal
- Accession number :
- 25555516
- Full Text :
- https://doi.org/10.1016/j.ghir.2014.12.005