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Neuroprotective naphthalene and flavan derivatives from Polygonum cuspidatum.
- Source :
-
Phytochemistry [Phytochemistry] 2015 Feb; Vol. 110, pp. 150-9. Date of Electronic Publication: 2014 Dec 29. - Publication Year :
- 2015
-
Abstract
- Ten naphthalene derivatives including two unusual glycosides possessing a naphthalene-fused piceid via a [C8'-O-C6-C5-C7']-trans-dihydrofuran ring, two flavan derivatives, as well as sixteen known phenolic compounds, were isolated from Polygonum cuspidatum. The structures were determined by extensive NMR, MS, CD data, and chemical evidence. In the in vitro neuroprotective assays, at the concentration of 10 μM, five of these compounds exhibited significant effects against PC12 cells injured by rotenone.<br /> (Copyright © 2014 Elsevier Ltd. All rights reserved.)
- Subjects :
- Algorithms
Animals
Flavonoids chemistry
Humans
Molecular Structure
Naphthalenes chemistry
Neuroprotective Agents chemistry
Nuclear Magnetic Resonance, Biomolecular
PC12 Cells
Rats
Fallopia japonica chemistry
Flavonoids isolation & purification
Flavonoids pharmacology
Naphthalenes isolation & purification
Naphthalenes pharmacology
Neuroprotective Agents isolation & purification
Neuroprotective Agents pharmacology
Rotenone pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3700
- Volume :
- 110
- Database :
- MEDLINE
- Journal :
- Phytochemistry
- Publication Type :
- Academic Journal
- Accession number :
- 25553583
- Full Text :
- https://doi.org/10.1016/j.phytochem.2014.12.007