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Quantitative hepatitis B core antibody level is a new predictor for treatment response in HBeAg-positive chronic hepatitis B patients receiving peginterferon.
- Source :
-
Theranostics [Theranostics] 2015 Jan 01; Vol. 5 (3), pp. 218-26. Date of Electronic Publication: 2015 Jan 01 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- A recent study revealed that quantitative hepatitis B core antibody (qAnti-HBc) level could serve as a novel marker for predicting treatment response. In the present study, we further investigated the predictive value of qAnti-HBc level in HBeAg-positive patients undergoing PEG-IFN therapy. A total of 140 HBeAg-positive patients who underwent PEG-IFN therapy for 48 weeks and follow-up for 24 weeks were enrolled in this study. Serum samples were taken every 12 weeks post-treatment. The predictive value of the baseline qAnti-HBc level for treatment response was evaluated. Patients were further divided into 2 groups according to the baseline qAnti-HBc level, and the response rate was compared. Additionally, the kinetics of the virological and biochemical parameters were analyzed. Patients who achieved response had a significantly higher baseline qAnti-HBc level (serological response [SR], 4.52±0.36 vs. 4.19±0.58, p=0.001; virological response [VR], 4.53±0.35 vs. 4.22±0.57, p=0.005; combined response [CR], 4.50±0.36 vs. 4.22±0.58, p=0.009)). Baseline qAnti-HBc was the only parameter that was independently correlated with SR (p=0.008), VR (p=0.010) and CR(p=0.019). Patients with baseline qAnti-HBc levels ≥30,000 IU/mL had significantly higher response rates, more HBV DNA suppression, and better hepatitis control in PEG-IFN treatment. In conclusion, qAnti-HBc level may be a novel biomarker for predicting treatment response in HBeAg-positive patients receiving PEG-IFN therapy.
- Subjects :
- Adult
Biomarkers blood
DNA, Viral blood
Female
Humans
Male
Middle Aged
Predictive Value of Tests
Prognosis
Viral Load
Young Adult
Drug Monitoring methods
Hepatitis B Antibodies blood
Hepatitis B Core Antigens immunology
Hepatitis B e Antigens blood
Hepatitis B, Chronic diagnosis
Hepatitis B, Chronic drug therapy
Interferon-alpha therapeutic use
Subjects
Details
- Language :
- English
- ISSN :
- 1838-7640
- Volume :
- 5
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Theranostics
- Publication Type :
- Academic Journal
- Accession number :
- 25553110
- Full Text :
- https://doi.org/10.7150/thno.10636