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Akt1 rs2498801 is related to survival in head and neck squamous cell cancer treated with radiotherapy.
- Source :
-
Anticancer research [Anticancer Res] 2015 Jan; Vol. 35 (1), pp. 269-71. - Publication Year :
- 2015
-
Abstract
- Background: Radiotherapy (RT) with or without chemotherapy (CT) plays an important role as exclusive treatment in patients with head and neck squamous cell cancer (HNSCC). Unfortunately, in some cases, benefit for patients is not recorded and only treatment-related complications are registered.<br />Materials and Methods: Data relating to Akt1 single nucleotide polymorphism (SNP) and response to treatment of 46 patients treated with exclusive RT or RT-CT for HNSCC were evaluated.<br />Results: For heterozygous patients median overall survival was 28.5 months, while for the wild-type group median overall survival was 10.9 (p=0.019). Three-year survival was 85% for mutated Akt1 homozygosis and 40% for patients with a heterozygous status (p=0.019, hazard ratio (HR)=7.960).<br />Conclusion: SNP of rs2498804 can recognize patients resistant to RT-CT. Further studies are needed to confirm our data and to investigate the role of Akt SNPs in HNSCC patients.<br /> (Copyright© 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Subjects :
- Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell radiotherapy
Female
Head and Neck Neoplasms mortality
Head and Neck Neoplasms radiotherapy
Humans
Kaplan-Meier Estimate
Male
Polymorphism, Single Nucleotide
Proportional Hazards Models
Radiation Tolerance genetics
Squamous Cell Carcinoma of Head and Neck
Carcinoma, Squamous Cell genetics
Head and Neck Neoplasms genetics
Proto-Oncogene Proteins c-akt genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 35
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 25550560