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[¹²³I]ICF01012 melanoma imaging and [¹³¹I]ICF01012 dosimetry allow adapted internal targeted radiotherapy in preclinical melanoma models.
- Source :
-
European journal of dermatology : EJD [Eur J Dermatol] 2015 Jan-Feb; Vol. 25 (1), pp. 29-35. - Publication Year :
- 2015
-
Abstract
- Background: Melanin-targeting radiotracers are interesting tools for imaging and treatment of pigmented melanoma metastases. However, variation of the pigment concentration may alter the efficiency of such targeting.<br />Objectives: A clear assessment of both tumor melanin status and dosimetry are therefore prerequisites for internal radiotherapy of disseminated melanoma.<br />Materials & Methods: The melanin tracer ICF01012 was labelled with iodine-123 for melanoma imaging in pigmented murine B16F0 and human SK-Mel 3 melanomas.<br />Results: In vivo imaging showed that the uptake of [(123)I]ICF01012 to melanomas correlated significantly with melanin content. Schedule treatment of 3 × 25 MBq [(131)I]ICF01012 significantly reduced SK-Mel 3 tumor growth and significantly increased the median survival in treated mice. For this protocol, the calculated delivered dose was 53.2 Gy.<br />Conclusion: Radio-iodinated ICF01012 is a good candidate for both imaging and therapeutic purposes for patients with metastatic pigmented melanomas.
- Subjects :
- Animals
Cell Line, Tumor
Humans
Iodine Radioisotopes
Male
Melanins metabolism
Melanoma pathology
Mice
Mice, Nude
Radiation Dosage
Skin Neoplasms
Melanoma, Cutaneous Malignant
Melanoma diagnostic imaging
Melanoma radiotherapy
Neoplasms, Experimental
Quinoxalines
Tomography, Emission-Computed, Single-Photon methods
Subjects
Details
- Language :
- English
- ISSN :
- 1952-4013
- Volume :
- 25
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- European journal of dermatology : EJD
- Publication Type :
- Academic Journal
- Accession number :
- 25548082
- Full Text :
- https://doi.org/10.1684/ejd.2014.2481