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"Long-acting" olanzapine in maintenance therapy of schizophrenia: A study with plasma levels.
- Source :
-
International journal of psychiatry in clinical practice [Int J Psychiatry Clin Pract] 2015 Jun; Vol. 19 (2), pp. 99-105. - Publication Year :
- 2015
-
Abstract
- Introduction: This prospective study was performed to evaluate clinical efficacy and tolerability of olanzapine long-acting injection (OLZ-LAI) and the relation between OLZ plasma level (PL) and the clinical outcome in maintenance therapy of schizophrenia.<br />Material and Methods: Twenty-five chronic schizophrenic outpatients with age ranging from 18 to 65 years were included in this 9-month study. Patients were given a dosage of either 210 or 300 or 405 mg of OLZ-LAI every 28 days. Patients were evaluated at baseline and every four weeks by Brief Psychiatric Rating Scale (BPRS) and Positive and Negative Symptom Scale (PANSS); at the same time, PL of OLZ was determined. The metabolic profile (aspartate aminotransferase, alanine aminotransferase, high-density lipoprotein, low-density lipoprotein, total cholesterol, and glucose levels) was analyzed every two months.<br />Results: BPRS and total PANSS showed a statistically significant improvement from T2 with a clinical stabilization of psychopathological picture. PL ranged from 4.0 to 78.9 ng/ml (mean 20.59 ng/ml ± 14.66 standard deviation). The coefficient of variation of PLs was related to clinical stabilization. No post-injection delirium sedation syndrome occurred.<br />Conclusions: Our data reveal the efficacy of OLZ-LAI in maintenance treatment of schizophrenia at lower dosages also in comparison with that of oral therapy. OLZ-LAI seems to be useful for guaranteeing constant PL of the drug. A lesser variation of PL was the most predictable factor associated with maintenance of clinical benefit.
- Subjects :
- Adult
Antipsychotic Agents administration & dosage
Antipsychotic Agents adverse effects
Benzodiazepines administration & dosage
Benzodiazepines adverse effects
Delayed-Action Preparations
Female
Follow-Up Studies
Humans
Injections
Male
Middle Aged
Olanzapine
Schizophrenia blood
Young Adult
Antipsychotic Agents blood
Antipsychotic Agents pharmacology
Benzodiazepines blood
Benzodiazepines pharmacology
Outcome Assessment, Health Care
Schizophrenia drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 1471-1788
- Volume :
- 19
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of psychiatry in clinical practice
- Publication Type :
- Academic Journal
- Accession number :
- 25547438
- Full Text :
- https://doi.org/10.3109/13651501.2014.1000928